6-氯-2-甲基-3-硝基吡啶合成路线 （共 26 条）
反应条件
1: palladium on carbon; hydrogen 2: tetrafluoroboric acid; EtO-NO 3: iodine; potassium acetate / acetic anhydride 4: ozone View Scheme
参考文献
Timperley, Christopher M.; Banks, R. Eric; Young, Ian M.; Haszeldine, Robert N.
Journal of Fluorine Chemistry, 2011 , vol. 132, # 8 p. 541 - 547
反应条件
1: With sodium T=0°C; 4 h; 2: With acetic acid
参考文献
Phenex Pharmaceuticals AG
Patent: EP1894924 A1, 2008 ;
Location in patent: Page/Page column 23 ;
参考文献
Eli Lilly and Company
Patent: US6358972 B1, 2002 ;
US 6358972 B1
参考文献
MERCK and CO., INC.
Patent: WO2009/155156 A1, 2009 ;
Location in patent: Page/Page column 74-75 ;
WO 2009/155156 A1
参考文献
Baumgarten; Su
Journal of the American Chemical Society, 1952 , vol. 74, p. 3828,3830
反应条件
1: palladium/charcoal; methanol / Hydrogenation 2: HNO2; SnCl2; aqueous HCl / -20 °C View Scheme
参考文献
Clemo; Holt
Journal of the Chemical Society, 1953 , p. 1313
反应条件
palladium on carbon; hydrogen
参考文献
Timperley, Christopher M.; Banks, R. Eric; Young, Ian M.; Haszeldine, Robert N.
Journal of Fluorine Chemistry, 2011 , vol. 132, # 8 p. 541 - 547
反应条件
1: 84 percent / hydrazine hydrate / Raney nickel / ethanol / 70 deg C, 10 min; room temperature, 0.5 h 2: 58 percent / aq. NaNO2, CuCl, HCl / 0.17 h / 50 °C View Scheme
参考文献
Ciurla; Puszko
Chemistry of Heterocyclic Compounds, 1996 , vol. 32, # 10 p. 1173 - 1177
反应条件
1: 84 percent / hydrazine hydrate / Raney nickel / ethanol / 70 deg C, 10 min; room temperature, 0.5 h 2: 54 percent / aq. NaNO2, CuBr, HBr View Scheme
参考文献
Ciurla; Puszko
Chemistry of Heterocyclic Compounds, 1996 , vol. 32, # 10 p. 1173 - 1177
反应条件
1.1: thiourea / ethanol / 7 h / Heating 1.2: 30 percent / aq. KOH / ethanol / 1 h / Heating 2.1: aq. HCl; Cl2 / 0.75 h / 5 °C 2.2: 40 percent / NH3(l) / 20 °C 3.1: H2 / Pd/C / ethanol View Scheme
参考文献
Romines, Karen R.; Freeman, George A.; Schaller, Lee T.; Cowan, Jill R.; Gonzales, Steve S.; Tidwell, Jeffrey H.; Andrews III, Clarence W.; Stammers, David K.; Hazen, Richard J.; Ferris, Robert G.; Short, Steven A.; Chan, Joseph H.; Boone, Lawrence R.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 2 p. 727 - 739
