3-(4-甲氧基苯基)丙酸合成路线 （共 50 条）
反应条件
1: 4-ethynyl-1-methoxy-benzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1.16667 h; 2: carbon dioxide in tetrahydrofuran; hexane T=-78°C; 3 h; 3: With water in tetrahydrofuran; hexane
参考文献
EURO-CELTIQUE S.A.
Patent: WO2005/56524 A2, 2005 ;
Location in patent: Page/Page column 114 ;
反应条件
1: ZTK-2-125 With n-butyllithium in tetrahydrofuran; hexane T=-78 - 0°C; 1.5 h; 2: carbon dioxide in tetrahydrofuran; hexane T=-78°C; 0.5 h; 3: With water in tetrahydrofuran; hexane
参考文献
Nissan Chemical Industries, Ltd.
Patent: US2009/23939 A1, 2009 ;
Location in patent: Page/Page column 20 ;
反应条件
bis-triphenylphosphine-palladium(II) chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1,4-di(diphenylphosphino)-butane in dimethyl sulfoxide T=50°C; Sonogashira coupling; 5 h; Sealed flask;
参考文献
Park, Kyungho; Palani, Thiruvengadam; Pyo, Ayoung; Lee, Sunwoo
Tetrahedron Letters, 2012 , vol. 53, # 7 p. 733 - 737
反应条件
formic acid T=40°C; 1 h;
参考文献
Kawate, Tomohiko; Iwase, Noriaki; Shimizu, Motohisa; Stanley, Sarah A.; Wellington, Samantha; Kazyanskaya, Edward; Hung, Deborah T.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 22 p. 6052 - 6059
反应条件
tetrakis(triphenylphosphine) palladium(0); 1,8-diazabicyclo[5.4.0]undec-7-ene in dimethyl sulfoxide T=35°C; Sonogashira Cross-Coupling; 24 h;
参考文献
Park, Kyungho; You, Jung-Min; Jeon, Seungwon; Lee, Sunwoo
European Journal of Organic Chemistry, 2013 , # 10 p. 1973 - 1978
反应条件
sodium dihydrogen phosphate monohydrate; cyclohexene in water; tert-butyl alcohol T=0 - 20°C; 10 h;
参考文献
Lima, Heather M.; Sivappa, Rasapalli; Yousufuddin, Muhammed; Lovely, Carl J.
Organic Letters, 2012 , vol. 14, # 9 p. 2274 - 2277
反应条件
1: With lithium hydroxide hydrate in tetrahydrofuran; methanol; water T=20°C; 2: With hydrogenchloride in water; ethyl acetate T=0°C; pH=4; 1 h;
参考文献
Hajbi, Youssef; Neagoie, Cleopatra; Biannic, Berenger; Chilloux, Aurelie; Vedrenne, Emeline; Baldeyrou, Brigitte; Bailly, Christian; Merour, Jean-Yves; Rosca, Sorin; Routier, Sylvain; Lansiaux, Amelie
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 11 p. 5428 - 5437
反应条件
1: With cesium fluoride in dimethyl sulfoxide T=20°C; 3 h; Schlenk technique; 2: With hydrogenchloride in water T=0°C; pH=> 1;
参考文献
Yonemoto-Kobayashi, Misato; Inamoto, Kiyofumi; Tanaka, Yoshiyuki; Kondo, Yoshinori
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 23 p. 3773 - 3775
反应条件
sodium hydroxide Heating; Yield given;
参考文献
Jacobsen, Eric N.; Deng, Li; Furukawa, Yoshiro; Martinez, Luis E.
Tetrahedron, 1994 , vol. 50, # 15 p. 4323 - 4334
反应条件
potassium hydroxide in ethanol 6 h; Reflux;
参考文献
Sun, Jie; Ding, Wei Xian; Zhang, Ke Yun; Zou, Yong
Chinese Chemical Letters, 2011 , vol. 22, # 6 p. 667 - 670
