2-(三氟甲基)吡啶 N-氧化物合成路线 （共 7 条）
反应条件
3-chloro-benzenecarboperoxoic acid in dichloromethane T=20°C; 72 h;
参考文献
Oguro, Yuya; Miyamoto, Naoki; Takagi, Terufumi; Okada, Kengo; Awazu, Yoshiko; Miki, Hiroshi; Hori, Akira; Kamiyama, Keiji; Imamura, Shinichi
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 20 p. 7150 - 7163
反应条件
1: H2, N,N-dimethylethylamine / 10percent Pd/C / methyl acetate / 1.5 h 2: H2O2, acetic acid View Scheme
参考文献
Webber; Bleckman; Attard; Deal; Kathardekar; Welsh; Janson; Matthews; Smith; Freer; Jordan; Bacquet; Howland; Booth; Ward; Hermann; White; Morse; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 6 p. 733 - 746
反应条件
sulfuric acid; nitric acid T=125 - 130°C; 3.5 h;
参考文献
Webber; Bleckman; Attard; Deal; Kathardekar; Welsh; Janson; Matthews; Smith; Freer; Jordan; Bacquet; Howland; Booth; Ward; Hermann; White; Morse; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 6 p. 733 - 746
反应条件
sulfuric acid; nitric acid T=130°C; 5 h;
参考文献
Oguro, Yuya; Miyamoto, Naoki; Takagi, Terufumi; Okada, Kengo; Awazu, Yoshiko; Miki, Hiroshi; Hori, Akira; Kamiyama, Keiji; Imamura, Shinichi
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 20 p. 7150 - 7163
反应条件
hydrogen; palladium on activated charcoal in ethanol P=1810.02 Torr; 0.75 h;
参考文献
Webber; Bleckman; Attard; Deal; Kathardekar; Welsh; Janson; Matthews; Smith; Freer; Jordan; Bacquet; Howland; Booth; Ward; Hermann; White; Morse; et al.
Journal of Medicinal Chemistry, 1993 , vol. 36, # 6 p. 733 - 746
反应条件
1: With sulfuric acid; nitric acid
T=0 - 125°C; 4 h;
2: With sodium hydroxide; water
pH=7;
参考文献
ASTRAZENECA AB
Patent: US2009/170849 A1, 2009 ;
Location in patent: Page/Page column 14 ;
US 20090170849 A1
反应条件
sulfuric acid; nitric acid
T=130°C; 5 h;
参考文献
Oguro, Yuya; Miyamoto, Naoki; Takagi, Terufumi; Okada, Kengo; Awazu, Yoshiko; Miki, Hiroshi; Hori, Akira; Kamiyama, Keiji; Imamura, Shinichi
Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 20 p. 7150 - 7163
