5-甲氧基-2,3-二氢异吲哚-1-酮合成路线 （共 14 条）
反应条件
ammonia in methanol T=130°C;
参考文献
Shen, Zhongqi; Siva Ramamoorthy; Hatzenbuhler, Nicole T.; Evrard, Deborah A.; Childers, Wayne; Harrison, Boyd L.; Chlenov, Michael; Hornby, Geoffrey; Smith, Deborah L.; Sullivan, Kelly M.; Schechter, Lee E.; Andree, Terrance H.
Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 1 p. 222 - 227
反应条件
hydrogen; nickel in methanol T=85°C; P=2585.81 Torr;
参考文献
PFIZER PRODUCTS INC.
Patent: WO2008/20306 A2, 2008 ;
Location in patent: Page/Page column 26; 27-28 ;
反应条件
ammonium cerium(IV) nitrate; water in acetonitrile T=20°C; 1 h;
参考文献
F. HOFFMANN-LA ROCHE AG
Patent: WO2004/14856 A1, 2004 ;
Location in patent: Page 10; 23 ;
反应条件
hydrogenchloride; tin in ethanol 12 h; Heating;
参考文献
Hennige, Hans; Kreher, Richard P.; Konrad, Michael; Jelitto, Frank
Chemische Berichte, 1988 , vol. 121, p. 243 - 252
反应条件
sodium hydroxide in water pH=9;
参考文献
Powers, James J.; Favor, David A.; Rankin, Trent; Sharma, Rashmi; Pandit, Chetan; Jeganathan, Azhwarsamy; Maiti, Samarendra N.
Tetrahedron Letters, 2009 , vol. 50, # 12 p. 1267 - 1269
反应条件
1.1: triethylamine / dichloromethane / 0 - 20 °C 1.2: 0.25 h / 20 °C 2.1: didodecanoyl peroxide / 1,2-dichloro-ethane / 4 h / Reflux 3.1: trifluoroacetic acid / 2.5 h / Reflux View Scheme
参考文献
Tetrahedron, , vol. 67, # 14 p. 2693 - 2701
反应条件
sodium hydroxide; water pH=9; Product distribution / selectivity;
参考文献
WO2008/20306 A2, ;
Page/Page column 26; 27 ;
反应条件
1: H2SO4 (65 percent SO3) / 3 h / 200 °C 2: NaOH / 2.5 h / 175 °C 3: 53 percent / K2CO3 / 2 h / 90 °C 4: 0.25 h / 170 °C 5: 60 percent / formamide / 2.5 h / Heating 6: 40 percent / Sn/HCl / ethanol / 12 h / Heating View Scheme
参考文献
Chemische Berichte, , vol. 121, p. 243 - 252
反应条件
1: 60 percent / formamide / 2.5 h / Heating 2: 40 percent / Sn/HCl / ethanol / 12 h / Heating View Scheme
参考文献
Chemische Berichte, , vol. 121, p. 243 - 252
反应条件
1: 53 percent / K2CO3 / 2 h / 90 °C 2: 0.25 h / 170 °C 3: 60 percent / formamide / 2.5 h / Heating 4: 40 percent / Sn/HCl / ethanol / 12 h / Heating View Scheme
参考文献
Chemische Berichte, , vol. 121, p. 243 - 252
