6-甲氧基-3,4-二氢-1(2H)-异喹啉合成路线 （共 26 条）
反应条件
sodium azide; sulfuric acid in benzene T=60°C; 4 h;
参考文献
Shanker, P. Sathya; Rao, G. S. R. Subba
Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, 1993 , vol. 32, # 12 p. 1209 - 1213
反应条件
PPA T=120°C; Cyclization; 1.5 h;
参考文献
Gao, Mingzhang; Wang, Min; Miller, Kathy D.; Sledge, George W.; Zheng, Qi-Huang
European Journal of Medicinal Chemistry, 2008 , vol. 43, # 10 p. 2211 - 2219
反应条件
PPA in acetone T=24°C; 2.5 h;
参考文献
Anderson, Wayne K.; Heider, Arvela R.; Raju, Natarajan; Yucht, Jeffery A.
Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2097 - 2102
反应条件
polyphosphoric acid T=120°C; 1 h;
参考文献
WO2012/97682 A1, ;
Page/Page column 134 ;
反应条件
methanesulfonic acid; hydroxylamine hydrochloride; sodium hydrogencarbonate in methanol; water
参考文献
US5334600 A1, ;
US5260316 A1, ;
US 5260316 A
反应条件
sodium azide in CH3 SO3 H
反应条件
potassium hydroxide; chloroformic acid ethyl ester Erhitzen des Reaktionsprodukts mit Phosphorylchlorid und wenig Phosphor(V)-oxid in Xylol auf 130grad-140grad;
参考文献
Yakugaku Zasshi, , vol. 79, p. 329,334
Chem.Abstr., , p. 16177
反应条件
PPA T=145°C; 0.166667 h;
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 12 p. 2208 - 2216
反应条件
1: 100 percent / thionyl chloride / toluene / 3 h / 55 - 60 °C 2: 1.) aq. sodium azide / 1.) acetone, 0 deg C, 0.5 h, 2.) toluene, 80 deg C, 0.5 h 3: 37 percent / polyphosphoric acid / acetone / 2.5 h / 24 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 11 p. 2097 - 2102
反应条件
1: 1.) aq. sodium azide / 1.) acetone, 0 deg C, 0.5 h, 2.) toluene, 80 deg C, 0.5 h 2: 37 percent / polyphosphoric acid / acetone / 2.5 h / 24 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 11 p. 2097 - 2102
