7-甲氧基-3,4-二氢-2H-异喹啉-1-酮合成路线 （共 14 条）
反应条件
sodium azide; methanesulfonic acid in chloroform T=0°C; Schmidt reaction;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 20, # 1 p. 222 - 227
反应条件
1: With methanesulfonic acid; phosphorous pentoxide T=130°C; Neat (no solvent); 2: 2-4-methoxyphenylethylcarbamic acid methyl ester T=140°C; 1 h; Neat (no solvent); 3: With water T=80°C;
参考文献
WO2005/5392 A1, ;
Page 75-76 ;
WO 2005/005392 A1
反应条件
hydrogen; palladium on activated charcoal in ethanol T=80°C; P=3102.9 Torr; 48 h;
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, p. 329 - 331
反应条件
1: T=145°C; 0.75 h; 2: With water
参考文献
WO2012/35078 A1, ;
Page/Page column 98 ;
WO 2012/035078 A1
反应条件
PPA T=145°C; 0.166667 h;
参考文献
Journal of Medicinal Chemistry, , vol. 30, # 12 p. 2208 - 2216
反应条件
1: Et3N / tetrahydrofuran 2: PPA / 140 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 11, # 14 p. 1885 - 1888
反应条件
1: SOCl2 / toluene / 3 h / 80 °C 2: NaN3 / m-xylene / 5 h / 120 °C 3: 75 percent / I2 / 1,2-dichloro-benzene / Heating; overnight 4: 90 percent / H2 / 10percent Pd/C / ethanol / 48 h / 80 °C / 3102.9 Torr View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, p. 329 - 331
反应条件
1: NaN3 / m-xylene / 5 h / 120 °C 2: 75 percent / I2 / 1,2-dichloro-benzene / Heating; overnight 3: 90 percent / H2 / 10percent Pd/C / ethanol / 48 h / 80 °C / 3102.9 Torr View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, p. 329 - 331
反应条件
1: 75 percent / I2 / 1,2-dichloro-benzene / Heating; overnight 2: 90 percent / H2 / 10percent Pd/C / ethanol / 48 h / 80 °C / 3102.9 Torr View Scheme
参考文献
Journal of Heterocyclic Chemistry, , vol. 22, p. 329 - 331
反应条件
potassium permanganate; water; acetone
参考文献
Yakugaku Zasshi, , vol. 79, p. 329,334
Chem.Abstr., , p. 16177
