3,4-二氢-2H-苯并[1,4]噁嗪-2-羧酸乙酯合成路线 （共 15 条）
反应条件
1: trimethylaluminum / toluene / 5.25 h / 50 - 110 °C / |Inert atmosphere 2: triethylamine / 1,4-dioxane / 12 h / 20 °C / |Reflux View Scheme
反应条件
ammonia in ethanol 14 h;
参考文献
Bourlot, Anne-Sophie; Sanchez, Isabel; Dureng, Georges; Guillaumet, Gerald; Massingham, Roy; Monteil, Andre; Winslow, Eileen; Pujol, M. Dolors; Merour, Jean-Yves
Journal of Medicinal Chemistry, 1998 , vol. 41, # 17 p. 3142 - 3158
反应条件
1: 67 percent / K2CO3 / acetone / 18 h / Heating 2: 93 percent / aq. KOH / methanol; tetrahydrofuran / 1 h / 20 °C View Scheme
参考文献
Bourlot, Anne-Sophie; Sanchez, Isabel; Dureng, Georges; Guillaumet, Gerald; Massingham, Roy; Monteil, Andre; Winslow, Eileen; Pujol, M. Dolors; Merour, Jean-Yves
Journal of Medicinal Chemistry, 1998 , vol. 41, # 17 p. 3142 - 3158
反应条件
1: 98 percent / LiAlH4 / tetrahydrofuran / 3.5 h / 0 - 20 °C
2: 1.) oxalyl chloride, DMSO, 2.) Et3N / 1.) CH2Cl2, -78 deg C, 1 h, 2.) CH2Cl2, -40 deg C, 15 min
3: 32 percent / Et3N / tetrahydrofuran; H2O / 8.5 h / 0 - 20 °C
4: 72 percent / NaCN, AcOH, MnO2 / 24 h / 20 - 25 °C
View Scheme
参考文献
Bourlot, Anne-Sophie; Guillaumet, Gerald; Merour, Jean-Yves
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 1 p. 191 - 196
反应条件
in water; toluene
T=40°C; 18 h;
参考文献
Bourlot, Anne-Sophie; Sanchez, Isabel; Dureng, Georges; Guillaumet, Gerald; Massingham, Roy; Monteil, Andre; Winslow, Eileen; Pujol, M. Dolors; Merour, Jean-Yves
Journal of Medicinal Chemistry, 1998 , vol. 41, # 17 p. 3142 - 3158
