3-(4-硝基苯基)丙-2-炔酸合成路线 （共 26 条）
反应条件
caesium carbonate in N,N-dimethyl-formamide T=24°C; 20 h;
参考文献
Yu, Dingyi; Tan, Mei Xuan; Zhang, Yugen
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 6 p. 969 - 974
反应条件
1: With lithium hydroxide hydrate in tetrahydrofuran; methanol; water T=20°C; 16 h; 2: With hydrogenchloride in water pH=4;
参考文献
GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; HENDRICKSON, Thomas, Francis; HO, Koc-Kan; SAUNDERS, Michael, David; STEVENS, Brian, John; SWIERCZEK, Krzysztof; WRIGHT, Kevin, Bret
Patent: WO2013/62945 A1, 2013 ;
Location in patent: Page/Page column 117 ;
WO 2013/062945 A1
反应条件
sodium hydroxide in tetrahydrofuran T=20°C; 12 h;
参考文献
European Journal of Medicinal Chemistry, , vol. 77, p. 351 - 360
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine in N,N-dimethyl-formamide T=20°C; Sonogashira coupling; 5 h; Inert atmosphere;
参考文献
Tetrahedron Letters, , vol. 53, # 32 p. 4248 - 4252
反应条件
tetrakis(triphenylphosphine) palladium(0); 1,8-diazabicyclo[5.4.0]undec-7-ene in dimethyl sulfoxide T=25°C; Sonogashira Cross-Coupling; 24 h;
参考文献
Park, Kyungho; You, Jung-Min; Jeon, Seungwon; Lee, Sunwoo
European Journal of Organic Chemistry, 2013 , # 10 p. 1973 - 1978
反应条件
1: With cesium fluoride in dimethyl sulfoxide T=20°C; 3 h; Schlenk technique; 2: With hydrogenchloride in water T=0°C; pH=> 1;
参考文献
Yonemoto-Kobayashi, Misato; Inamoto, Kiyofumi; Tanaka, Yoshiyuki; Kondo, Yoshinori
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 23 p. 3773 - 3775
反应条件
1: sodium ethylate; benzene; ethanol 2: aqueous NaOH View Scheme
参考文献
Journal of the American Chemical Society, , vol. 77, p. 5549
反应条件
nitric acid T=-18°C;
参考文献
Journal of the Chemical Society, , p. 1267,1269
反应条件
1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 12 h / 20 °C / |Inert atmosphere 2.1: lithium hydroxide hydrate / tetrahydrofuran; methanol; water / 16 h / 20 °C 2.2: pH 4 View Scheme
参考文献
WO2013/62945 A1, ;
WO 2013/062945 A1
反应条件
1: Br2 / acetic acid 2: KOtBu View Scheme
参考文献
Helvetica Chimica Acta, , vol. 54, p. 2060 - 2068
