N-alpha-Cbz-L-赖氨酸合成路线 （共 34 条）
反应条件
1: 77 percent / Na2<Fe(III)(CN)5NO>*2H2O, 4M NaOH / H2O / 6.5 h / 60 °C / pH 9.5 2: NEt3, sodium sulphate / acetone / 18 h View Scheme
参考文献
Schmitt, Martin L.; Hauser, Alexander-Thomas; Carlino, Luca; Pippel, Martin; Schulz-Fincke, Johannes; Metzger, Eric; Willmann, Dominica; Yiu, Teresa; Barton, Michelle; Schuele, Roland; Sippl, Wolfgang; Jung, Manfred
Journal of Medicinal Chemistry, 2013 , vol. 56, # 18 p. 7334 - 7342
反应条件
1: NaNO2 / acetic acid 2: DCC 3: K2CO3 / methanol 4: Et3N 5: 90 percent / H2, K2CO3 / 10percent Pd/C / ethanol View Scheme
参考文献
Adger, Brian; Dyer, Ulrich; Hutton, Gordon; Woods, Martin
Tetrahedron Letters, 1996 , vol. 37, # 35 p. 6399 - 6402
反应条件
sodium cyanoborohydride in water T=100°C; 4 h;
参考文献
Walton, Donald J.; Ison, Edward R.; Szarek, Walter A.
Carbohydrate Research, 1984 , vol. 128, p. 37 - 50
反应条件
hydrogen; acetic acid; sodium nitrite 1.) H2O, THF, 22 h, 15 - 50 deg C, 2.) MeOH, H2O, RT, 5 h; Yield given. Multistep reaction;
参考文献
Nevill Jr., C. Richard; Angell, Paul T.
Tetrahedron Letters, 1998 , vol. 39, # 32 p. 5671 - 5674
反应条件
1: sodium nitrite / water; acetic acid / 0 - 90 °C 2: hydrogenchloride; water / acetic acid / 0.5 h / 90 °C View Scheme
参考文献
Liu, Yahua; Zhang, Weihan; Sayre, Lawrence M.
Journal of Heterocyclic Chemistry, 2011 , vol. 48, # 2 p. 426 - 433
反应条件
sodium salt of phosphorous acid T=37°C; 24 h; Further byproducts given;
参考文献
Chemistry and Physics of Lipids, , vol. 75, # 1 p. 43 - 50
反应条件
sodium salt of phosphorous acid T=37°C; 24 h; Mechanism;
参考文献
Chemistry and Physics of Lipids, , vol. 75, # 1 p. 43 - 50
反应条件
2: DCC / ethyl acetate View Scheme
参考文献
Schnabel,E.
Justus Liebigs Annalen der Chemie, 1964 , vol. 674, p. 218 - 225
反应条件
sodium hydrogencarbonate in tetrahydrofuran; water T=20°C;
参考文献
WO2007/127173 A2, ;
Page/Page column 34 ;
参考文献
Journal of the American Chemical Society, , vol. 87, p. 99 - 104
