1-(2-氨基-4-氯-5-甲基苯基)-2-氯乙烷酮合成路线 （共 4 条）
反应条件
diethylaluminium chloride; boron trichloride in n-heptane; 1,2-dichloro-ethane 3 h; Heating / reflux;
参考文献
Societe de Conseils de Recherches et d'Applications Scientifiques (S.C.R.A.S.)
Patent: US6339091 B1, 2002 ;
Location in patent: Example 82 ;
反应条件
1: aluminium chloride; carbon disulfide View Scheme
参考文献
Kunckell; Lillig
Journal fuer Praktische Chemie (Leipzig), 1912 , vol. <2> 86, p. 518
参考文献
Kunckell; Lillig
Journal fuer Praktische Chemie (Leipzig), 1912 , vol. <2> 86, p. 518
反应条件
1: Et3N / acetonitrile / 20 °C
2: 83 percent / EtONa / ethanol / 20 °C
3: 85 percent / POCl3 / Heating
4: 74 percent / Dibal / CH2Cl2 / 20 °C
5: 93 percent / tetrahydrofuran / 20 °C
View Scheme
参考文献
Lavergne, Olivier; Harnett, Jeremiah; Rolland, Alain; Lanco, Christophe; Lesueur-Ginot, Laurence; Demarquay, Daniele; Huchet, Marion; Coulomb, Helene; Bigg, Dennis C. H.
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 17 p. 2599 - 2602
