potassium carbonate in methanol T=25°C; 24 h; Inert atmosphere;

potassium phosphate; potassium hydroxide in toluene Inert atmosphereReflux;

1.1: sodium hydride / tetrahydrofuran / 20 °C / Inert atmosphere 1.2: 2 h / 20 °C / Inert atmosphere 2.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 2 h / 20 °C / Inert atmosphere 3.1: methanol; potassium carbonate / tetrahydrofuran / 17 h / 20 °C / Inert atmosphere View Scheme

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / 2 h / 20 °C / Inert atmosphere 2: methanol; potassium carbonate / tetrahydrofuran / 17 h / 20 °C / Inert atmosphere View Scheme

1: triethylamine; copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / |Inert atmosphere; |Reflux 2: potassium hydroxide; potassium phosphate / toluene / |Inert atmosphere; |Reflux View Scheme

1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / |Inert atmosphere; |Cooling with ice 2: tetrabutyl ammonium fluoride / tetrahydrofuran / 0.5 h / 0 °C / |Inert atmosphere View Scheme