5-氯-6-甲氧基烟酸甲酯合成路线 （共 4 条）
反应条件
1: With sulfuric acid T=60°C; 20 h; 2: With sodium hydrogencarbonate in water; ethyl acetate
参考文献
Bolli, Martin; Lescop, Cyrille; Mathys, Boris; Mueller, Claus; Nayler, Oliver; Steiner, Beat; Velker, Jorg
Patent: US2011/212998 A1, 2011 ;
Location in patent: Page/Page column 24 ;
US 20110212998 A1
反应条件
bis-triphenylphosphine-palladium(II) chloride; sodium acetate; 1,4-di(diphenylphosphino)-butane in tetrahydrofuran T=150°C; P=11250.9 Torr; 6 h; Further byproducts given;
参考文献
Bessard, Yves; Roduit, Jean Paul
Tetrahedron, 1999 , vol. 55, # 2 p. 393 - 404
反应条件
1: sodium / Reflux 2: sulfuric acid / 20 h / 60 °C View Scheme
参考文献
Bolli, Martin; Lescop, Cyrille; Mathys, Boris; Mueller, Claus; Nayler, Oliver; Steiner, Beat; Velker, Jorg
Patent: US2011/212998 A1, 2011 ;
US 20110212998 A1
反应条件
1: With water; lithium hydroxide hydrate in tetrahydrofuran T=20°C; 2.5 h; 2: With acetic acid in tetrahydrofuran
参考文献
WO2010/146351 A1, ;
Page/Page column 62-63 ;
WO 2010/146351 A1
