4-羟基-3-三氟甲基苯甲醛合成路线 （共 3 条）
反应条件
1: With 1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane; trifluoroacetic acid T=65°C; 18 h; 2: With hydrogenchloride in water
参考文献
WYETH
Patent: WO2005/37807 A1, 2005 ;
Location in patent: Page/Page column 218-219 ;
WO 2005/037807 A1
反应条件
1,3,5,7-tetra-azatricyclo[5.1.1.13,5]decane T=65°C; 18 h;
参考文献
WYETH
Patent: WO2005/37207 A2, 2005 ;
Location in patent: Page/Page column 209-210 ;
WO 2005/037207 A2
反应条件
potassium carbonate in ethanol
T=20°C; 48 h;
参考文献
Cheng, Xue Qin; Chen, Xingqiang; Hughes, Richard A.; Williams, Spencer J.; Woodman, Owen L.
Journal of Medicinal Chemistry, 2008 , vol. 51, # 6 p. 1874 - 1884
