甲基4-氟-1-苯并噻吩-2-羧酸酯合成路线 （共 7 条）
反应条件
NaH in dimethyl sulfoxide
参考文献
Eisai Co., Ltd.
Patent: US5340833 A1, 1994 ;
US 5340833 A
反应条件
1: 4-fluoro-benzo(b)thiophen-2-carboxylic acid With oxalyl dichloride; N,N-dimethyl-formamide in dichloromethane T=20°C; 18 h; 2: methanol in dichloromethane T=20°C; 18 h;
参考文献
US2012/53347 A1, ;
Page/Page column 71 ;
反应条件
in dichloromethane T=20°C; 18 h;
参考文献
WO2007/134107 A2, ;
Page/Page column 215-216 ;
WO 2007/134107 A2
反应条件
1.1: LDA / tetrahydrofuran / -78 °C 1.2: tetrahydrofuran 2.1: K2CO3 / dimethylformamide View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 12 p. 2998 - 3001
反应条件
1: potassium hydroxide / water; ethanol / 2 h / |Reflux 2: quinoline; copper / 2 h / 185 °C View Scheme
参考文献
Li, Chung-Yen; Su, Chaochin; Wang, Hsiou-Hsuan; Kumaresan, Prabakaran; Hsu, Chia-Hsuan; Lee, I-Ting; Chang, Wei-Chun; Tingare, Yogesh S.; Li, Ting-Yu; Lin, Chia-Feng; Li, Wen-Ren
Dyes and Pigments, 2014 , vol. 100, # 1 p. 57 - 65
反应条件
potassium hydroxide in ethanol; water 2 h; Reflux;
参考文献
Li, Chung-Yen; Su, Chaochin; Wang, Hsiou-Hsuan; Kumaresan, Prabakaran; Hsu, Chia-Hsuan; Lee, I-Ting; Chang, Wei-Chun; Tingare, Yogesh S.; Li, Ting-Yu; Lin, Chia-Feng; Li, Wen-Ren
Dyes and Pigments, 2014 , vol. 100, # 1 p. 57 - 65
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran
T=0°C; 1 h;
2: With water in tetrahydrofuran
参考文献
Colburn, Raymond W.; Dax, Scott L.; Flores, Christopher; Matthews, Jay; Qin, Ning; Reany, Laura; Teleha, Christopher; Youngman, Mark A.
Patent: US2012/184510 A1, 2012 ;
Location in patent: Page/Page column 71 ;
US 20120184510 A1
