2-[(叔丁氧基羰基)氨基]-5-(三氟甲氧基)苯甲酸合成路线 （共 6 条）
反应条件
1: tert-butyl N-(4-trifluoromethoxyphenyl)carbamate With tert.-butyl lithium in tetrahydrofuran; pentane T=-50°C; 2 h; 2: carbon dioxide in tetrahydrofuran; pentane T=25°C;
参考文献
Leroux, Frederic; Castagnetti, Eva; Schlosser, Manfred
Journal of Organic Chemistry, 2003 , vol. 68, # 12 p. 4693 - 4699
反应条件
1: tert-butyl N-(4-trifluoromethoxyphenyl)carbamate With sec.-butyllithium in tetrahydrofuran T=-78 - -40°C; 2.75 h; 2: carbon dioxide in tetrahydrofuran T=-40 - -20°C; 0.5 h; 3: With water; ammonium chloride
参考文献
Carter, Percy H.; Cherney, Robert J.; Batt, Douglas G.; Duncia, John V.; Gardner, Daniel S.; Ko, Soo S.; Srivastava, Anurag S.; Yang, Michael G.
Patent: US2005/54627 A1, 2005 ;
Location in patent: Page/Page column 41 ;
US 20050054627 A1
反应条件
1.1: 99 percent / toluene / 100 °C 2.1: t-BuLi / pentane; tetrahydrofuran / 2 h / -50 °C 2.2: 81 percent / pentane; tetrahydrofuran / 25 °C View Scheme
参考文献
Schlosser, Manfred; Castagnetti
European Journal of Organic Chemistry, 2001 , # 21 p. 3991 - 3997
反应条件
1.1: 99 percent / toluene / 100 °C 2.1: t-BuLi / pentane; tetrahydrofuran / 2 h / -50 °C 2.2: 81 percent / pentane; tetrahydrofuran / 25 °C View Scheme
参考文献
Schlosser, Manfred; Castagnetti
European Journal of Organic Chemistry, 2001 , # 21 p. 3991 - 3997
反应条件
trifluoroacetic acid in dichloromethane T=25°C; 2 h;
参考文献
Leroux, Frederic; Castagnetti, Eva; Schlosser, Manfred
Journal of Organic Chemistry, 2003 , vol. 68, # 12 p. 4693 - 4699
反应条件
1: With hydrogenchloride in 1,4-dioxane
T=20°C; 6 h;
2: With hydrogenchloride in 1,4-dioxane; dichloromethane; water
T=20°C;
参考文献
Carter, Percy H.; Cherney, Robert J.; Batt, Douglas G.; Brown, Gregory D.; Duncia, John V.; Gardner, Daniel S.; Yang, Michael G.
Patent: US2005/54626 A1, 2005 ;
Location in patent: Page/Page column 39 ;
US 20050054626 A1
