3-甲基-4-羟基喹喔啉-2-羧酸乙酯合成路线 （共 6 条）
反应条件
aniline Erhitzen des Reaktionsprodukts in Mineraloel auf 255grad;
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
in diphenylether T=250°C; 1 h;
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
1: p-TsOH*H2O / toluene / Heating 2: 2.42 g / diphenyl ether / 1 h / 250 °C View Scheme
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
1: aq. NaOH / 2.5 h / Heating 2: 231 mg / diphenyl ether / 1 h / 250 °C 3: 83 percent / phosphorus oxychloride / 1 h / 105 °C View Scheme
参考文献
Steck et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 132
反应条件
thionyl chloride; N,N-dimethyl-formamide
T=80°C; 1 h;
参考文献
Hoeglund, Iisa P. J.; Silver, Satu; Engstroem, Mia T.; Salo, Harri; Tauber, Andrei; Kyyroenen, Hanna-Kaisa; Saarenketo, Pauli; Hoffren, Anna-Marja; Kokko, Kurt; Pohjanoksa, Katariina; Sallinen, Jukka; Savola, Juha-Matti; Wurster, Siegfried; Kallatsa, Oili A.
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6351 - 6363
反应条件
1: aq. NaOH / 2.5 h / Heating
2: 231 mg / diphenyl ether / 1 h / 250 °C
View Scheme
参考文献
Steck et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 132
