3-甲基-1H-咪唑并[4,5-b]吡啶-2(3H)-酮合成路线 （共 10 条）
反应条件
trichlorophosphate Chlorination; 1.5 h; Heating;
参考文献
Oguchi; Wada; Honma; Tanaka; Kaneko; Sakakibara; Ohsumi; Serizawa; Fujiwara; Horikoshi; Fujita
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3052 - 3066
反应条件
sodium hydroxide in water
T=70°C; 0.333333 h;
参考文献
Zecchini; Torrini; Paradisi
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 4 p. 1061 - 1064
反应条件
in dichloromethane
Carbonylation; 2 h; Heating;
参考文献
Oguchi; Wada; Honma; Tanaka; Kaneko; Sakakibara; Ohsumi; Serizawa; Fujiwara; Horikoshi; Fujita
Journal of Medicinal Chemistry, 2000 , vol. 43, # 16 p. 3052 - 3066
反应条件
1: tetrahydrofuran / 80 °C
2: hydrogen / palladium 10 on activated carbon / ethanol / 20 °C
3: tetrahydrofuran / 5 h / Reflux
View Scheme
参考文献
TANIGUCHI, Takahiko; YOSHIKAWA, Masato; MIURA, Kasei; HASUI, Tomoaki; HONDA, Eiji; IMAMURA, Keisuke; KAMATA, Makoto; KAMISAKI, Haruhi; QUINN, John F.; RAKER, Joseph; CAMARA, Fatoumata; WANG, Yi
Patent: US2011/319394 A1, 2011 ;
反应条件
1: hydrogen / palladium 10 on activated carbon / ethanol / 20 °C
2: tetrahydrofuran / 5 h / Reflux
View Scheme
参考文献
TANIGUCHI, Takahiko; YOSHIKAWA, Masato; MIURA, Kasei; HASUI, Tomoaki; HONDA, Eiji; IMAMURA, Keisuke; KAMATA, Makoto; KAMISAKI, Haruhi; QUINN, John F.; RAKER, Joseph; CAMARA, Fatoumata; WANG, Yi
Patent: US2011/319394 A1, 2011 ;
反应条件
1: 4.2 percent / tetrahydrofuran; pyridine / 1) 0 deg C, 15 min.; 2) room temp., 3 h
2: 0.064 g / ethyl acetate; methanol; diethyl ether / 0.75 h / 0 °C
3: H2O / 0.5 h / Heating
View Scheme
参考文献
Zecchini; Torrini; Paradisi
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 4 p. 1061 - 1064
反应条件
1: 0.044 g / ethyl acetate; methanol; diethyl ether / 0.25 h / 0 °C / Heating
2: 93 percent / 0.5 N NaOH / H2O / 0.33 h / 70 °C
View Scheme
参考文献
Zecchini; Torrini; Paradisi
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 4 p. 1061 - 1064
反应条件
1: 73 percent / 2N aq. HCl / tetrahydrofuran / 4 h / Heating
2: 0.064 g / ethyl acetate; methanol; diethyl ether / 0.75 h / 0 °C
3: H2O / 0.5 h / Heating
View Scheme
参考文献
Zecchini; Torrini; Paradisi
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 4 p. 1061 - 1064
反应条件
in water
0.5 h; Heating; Yield given;
参考文献
Zecchini; Torrini; Paradisi
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 4 p. 1061 - 1064
反应条件
1: 0.064 g / ethyl acetate; methanol; diethyl ether / 0.75 h / 0 °C
2: H2O / 0.5 h / Heating
View Scheme
参考文献
Zecchini; Torrini; Paradisi
Journal of Heterocyclic Chemistry, 1985 , vol. 22, # 4 p. 1061 - 1064
