3,5-二甲基-2-吡咯甲醛合成路线 （共 24 条）
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=0°C; 0.333333 h; 2: 2,4-dimethyl pyrrole in 1,2-dichloro-ethane T=0°C; 0.5 h; Heating / reflux; 3: With sodium acetate in 1,2-dichloro-ethane 0.333333 h; Heating / reflux;
参考文献
Bristol Myers Squibb Company
Patent: US6982265 B1, 2006 ;
Location in patent: Page/Page column 28 ;
反应条件
1: N,N-dimethyl-formamide With trichlorophosphate T=0 - 20°C; Inert atmosphere; 2: 2,4-dimethyl pyrrole in 1,2-dichloro-ethane T=0°C; 0.833333 h; Reflux; 3: With water; sodium acetate in 1,2-dichloro-ethane 0.5 h; Reflux;
参考文献
Wu, Liangxing; Burgess, Kevin
Chemical Communications, 2008 , # 40 p. 4933 - 4935
反应条件
in N-methyl-acetamide; water
参考文献
Sugen, Inc.
Patent: US6147106 A1, 2000 ;
US 6147106 A
反应条件
1: 2,4-dimethyl pyrrole With trichlorophosphate in 1,2-dichloro-ethane; N,N-dimethyl-formamide 0.25 h; RefluxSchlenk techniqueInert atmosphere; 2: sodium acetate in water; 1,2-dichloro-ethane; N,N-dimethyl-formamide 0.25 h; Reflux;
参考文献
Liu, Xiaohui; Nan, Hongmei; Sun, Wei; Zhang, Qikai; Zhan, Mingjian; Zou, Luyi; Xie, Zhiyuan; Li, Xiao; Lu, Canzhong; Cheng, Yanxiang
Dalton Transactions, 2012 , vol. 41, # 34 p. 10199 - 10210
反应条件
hydrogenchloride; diethyl ether Zersetzen des Reaktionsprodukts mit kalter Natronlauge;
参考文献
Chemische Berichte, , vol. 55, p. 1949
Chemische Berichte, , vol. 56, p. 520,523
反应条件
1: concentrated aqueous KOH-solution / 160 °C 2: hydrogen chloride View Scheme
参考文献
Journal of the American Chemical Society, , vol. 63, p. 1829,1831
反应条件
trichlorophosphate T=60°C;
参考文献
Rend.Accad.Bologna, , vol. <11>3, p. 16,22
反应条件
trifluoroacetic acid 1) 5 min, room temperature 2) 5 min, 0 deg C; Yield given. Multistep reaction;
参考文献
Journal of Organic Chemistry, , vol. 49, # 24 p. 4602 - 4609
反应条件
1: ethylene glycol; potassium hydroxide; monohydrazine sulfate / 1 h / Reflux; without air access 2: trichlorophosphate / 1.5 h / 20 °C View Scheme
参考文献
Russian Journal of General Chemistry, , vol. 80, # 11 p. 2374 - 2381
参考文献
Atti della Accademia Nazionale dei Lincei, Classe di Scienze Fisiche, Matematiche e Naturali, Rendiconti, , vol. <5>24, p. II 198
Gazzetta Chimica Italiana, , vol. 51, p. I 282
