2,3,5-三甲基-1H-吡咯合成路线 （共 37 条）
反应条件
1: 2,3,5-trimethyl-1H-pyrrole; carbon disulfide With potassium hydroxide in dimethyl sulfoxide T=20°C; 3 h; 2: ethyl iodide in dimethyl sulfoxide T=20°C; 2 h;
参考文献
Trofimov, Boris A.; Sobenina, Lubov' N.; Mikhaleva, Al'bina I.; Demenev, Andrey P.; Tarasova, Ol'ga A.; Ushakov, Igor' A.; Zinchenko, Sergey V.
Tetrahedron, 2000 , vol. 56, # 37 p. 7325 - 7329
反应条件
1: ethanol; sodium ethylate / unter Kuehlung,und Einleiten von Kohlendioxid in die wss.Loesung des erhaltenen Reaktionsprodukts 2: aqueous HCl 3: aqueous HNO3 View Scheme
参考文献
Ajello; Petronici
Gazzetta Chimica Italiana, 1942 , vol. 72, p. 333,341
反应条件
sodium methylate T=200 - 235°C; im Rohr;
参考文献
Fischer,H.; Bartholomaeus
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1912 , vol. 80, p. 15
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Fischer,H.; Roese
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1913 , vol. 87, p. 42
Chemische Berichte, 1914 , vol. 47, p. 796
反应条件
hydrogenchloride Reduktion des Reaktionsprodukts mit Jodwasserstoffsaeure in Eisessig;
参考文献
Fischer,H.; Bartholomaeus
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1913 , vol. 83, p. 58
Full Text Show Details
Fischer,H.; Roese
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1912 , vol. 82, p. 394
参考文献
Fischer,H.; Bartholomaeus
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1912 , vol. 80, p. 15
Full Text Show Details
Fischer,H.; Roese
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1913 , vol. 87, p. 42
Chemische Berichte, 1914 , vol. 47, p. 796
参考文献
Fischer,H.; Bartholomaeus
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1912 , vol. 80, p. 15
Full Text Show Details
Fischer,H.; Roese
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1913 , vol. 87, p. 42
Chemische Berichte, 1914 , vol. 47, p. 796
反应条件
Reduktion des Reaktionsprodukts mit Jodwasserstoffsaeure und Eisessig;
参考文献
Fischer,H.; Bartholomaeus
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1913 , vol. 83, p. 58
Full Text Show Details
Fischer,H.; Roese
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1912 , vol. 82, p. 394
反应条件
potassium hydroxide in ethylene glycol
Decarboxylation; ester cleavage; 2 h; Heating;
参考文献
Berezin; Semeikin; Antina; Pashanova; Lehedeva; Bukushina
Russian Journal of General Chemistry, 1999 , vol. 69, # 12 p. 1949 - 1955
反应条件
1: malononitrile With potassium hydroxide in dimethyl sulfoxide
T=20°C; 0.5 h;
2: ethyl 2,4,5-trimethylpyrrole-3-carbodithioate in dimethyl sulfoxide
T=110°C; 1.5 h;
3: ethyl iodide in dimethyl sulfoxide
T=20°C; 2 h;
参考文献
Trofimov, Boris A.; Demenev, Andrey P.; Sobenina, Lyubov' N.; Mikhaleva, Al'bina I.; Tarasova, Ol'ga A.
Tetrahedron Letters, 2003 , vol. 44, # 17 p. 3501 - 3503
反应条件
methanol; nickel
T=120°C; P=73550.8 Torr; Hydrogenation;
参考文献
Johnson et al.
Journal of the Chemical Society, 1958 , p. 4254
Org. Synth. Coll. Vol. V. <1973> 1022
