4-氰基-2-甲氧基苯甲醛合成路线 （共 9 条）
反应条件
sodium periodate; osmium(VIII) oxide; N-benzyl-N,N,N-triethylammonium chloride in tetrahydrofuran; water T=20 - 30°C; 2 h;
参考文献
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT
Patent: US2010/305052 A1, 2010 ;
Location in patent: Page/Page column 8; 18 ;
反应条件
silver nitrate in ethanol; water 0.5 h; Heating;
参考文献
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Patent: EP1719767 A1, 2006 ;
Location in patent: Page/Page column 24-26; 28; 33 ;
反应条件
lithium tri-t-butoxyaluminum hydride in tetrahydrofuran; diethylene glycol dimethyl ether T=-78°C; 3.5 h;
参考文献
Farina, Carlo; Gagliardi, Stefania; Rahman, Shahzad Sharooq
Patent: US2005/38095 A1, 2005 ;
Location in patent: Page/Page column 9 ;
US 20050038095 A1
反应条件
Dess-Martin periodane in dichloromethane T=20°C; 20 h;
参考文献
WO2006/60461 A1, ;
Page/Page column 197-198 ;
WO 2006/060461 A1
反应条件
1: 77 percent / N-bromosuccinimide; benzoyl peroxide / CCl4 / 3 h / Heating 2: 99 percent / AgNO3 / H2O; ethanol / 0.5 h / Heating View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 50, # 10 p. 2468 - 2485
反应条件
1: triethylamine; magnesium chloride / acetonitrile / 80 °C 2: potassium carbonate / N,N-dimethyl-formamide / 120 °C 3: N,N-dimethyl-formamide / 90 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 9 p. 3223 - 3228
反应条件
1: potassium carbonate / N,N-dimethyl-formamide / 120 °C 2: N,N-dimethyl-formamide / 90 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 9 p. 3223 - 3228
反应条件
in N,N-dimethyl-formamide T=90°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 9 p. 3223 - 3228
反应条件
1: With boron tribromide in dichloromethane T=-78 - 20°C; Inert atmosphere; 2: With sodium hydrogencarbonate in dichloromethane
参考文献
US2010/305052 A1, ;
Page/Page column 20-21 ;
