4-(溴甲基)-3-氯苯甲腈合成路线

21423-81-43-氯-4-甲基苯甲腈→21924-83-44-(溴甲基)-3-氯苯甲腈

参考文献

Taylor, Steven J.; Soleymanzadeh, Fariba; Eldrup, Anne B.; Farrow, Neil A.; Muegge, Ingo; Kukulka, Alison; Kabcenell, Alisa K.; Lombaert, Stephane De
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 20 p. 5864 - 5868

34241-39-9+21423-81-43-氯-4-甲基苯甲腈→21924-83-44-(溴甲基)-3-氯苯甲腈

参考文献

Thorogood; Peter B.; Vinter; Jeremy G.
Patent: US4562199 A1, 1985 ;

59748-90-24-溴-2-氯苯甲酸→21924-83-44-(溴甲基)-3-氯苯甲腈

参考文献

PROXIMAGEN LIMITED; MEO, Paul; STEWART, Alison; HOBBS, Christopher
Patent: WO2014/20351 A1, 2014 ;

185315-48-44-溴-2-氯苄醇→21924-83-44-(溴甲基)-3-氯苯甲腈

参考文献

PROXIMAGEN LIMITED; MEO, Paul; STEWART, Alison; HOBBS, Christopher
Patent: WO2014/20351 A1, 2014 ;

21924-83-44-(溴甲基)-3-氯苯甲腈→467442-07-54-溴甲基-3-氯苯甲酸

参考文献

ARGENTA DISCOVERY LTD.
Patent: WO2007/36743 A2, 2007 ;
Location in patent: Page/Page column 145-16 ;
WO 2007/036743 A2

79-46-92-硝基丙烷+21924-83-44-(溴甲基)-3-氯苯甲腈→58588-64-03-氯-4-甲酰基苯甲腈

参考文献

THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
Patent: EP1719767 A1, 2006 ;
Location in patent: Page/Page column 24-28; 41 ;

21924-83-44-(溴甲基)-3-氯苯甲腈→58588-64-03-氯-4-甲酰基苯甲腈

参考文献

Patrick, Donald A.; Bakunov, Stanislav A.; Bakunova, Svetlana M.; Kumar, E.V.K. Suresh; Lombardy, Richard J.; Jones, Susan Kilgore; Bridges, Arlene S.; Zhirnov, Oksana; Hall, James Edwin; Wenzler, Tanja; Brun, Reto; Tidwell, Richard R.
Journal of Medicinal Chemistry, 2007 , vol. 50, # 10 p. 2468 - 2485