3-(苯基氨基)丙酸甲酯合成路线 （共 19 条）
反应条件
acetic acid; 1-phenyl-1-(pyridin-2-yl)methanol in acetonitrile T=110°C; 240 h; Inert atmosphere;
参考文献
Giomi, Donatella; Alfini, Renzo; Brandi, Alberto
Tetrahedron, 2011 , vol. 67, # 1 p. 167 - 172
反应条件
aluminum oxide T=100 - 110°C; 3 h;
参考文献
Tetrahedron, , vol. 70, # 14 p. 2449 - 2454
反应条件
silica-supported aluminum chloride T=60°C; Michael addition; 4 h; Neat (no solvent);
参考文献
Saidi, Mohammad R.; Pourshojaei, Yaghoub; Aryanasab, Fezzeh
Synthetic Communications, 2009 , vol. 39, # 6 p. 1109 - 1119
参考文献
Journal of pharmaceutical sciences, , vol. 61, # 11 p. 1739 - 1745
反应条件
1: pyridine / 0.33 h / Heating 2: aq. HCl / dioxane / 3 h / Heating 3: 1.) PCl5, 2.) AlCl3 / 1.) benzene, from 5 deg C to 23 deg C, 30 min, 2.) benzene 15-20 deg C, 3.5 h 4: 83 percent / gl. AcOH, aq. HCl / 3.5 h / Heating View Scheme
参考文献
Johnson; Woroch; Buell
Journal of the American Chemical Society, 1949 , vol. 71, p. 1901,1905
反应条件
1: pyridine / 0.33 h / Heating 2: aq. HCl / dioxane / 3 h / Heating 3: 1.) PCl5, 2.) AlCl3 / 1.) benzene, from 5 deg C to 23 deg C, 30 min, 2.) benzene 15-20 deg C, 3.5 h View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 28, # 11 p. 837 - 852
反应条件
T=100 - 110°C; 168 h;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 29, # 9 p. 2525 - 2530
反应条件
T=100 - 110°C; 168 h; sealed tube;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 29, # 9 p. 2525 - 2530
反应条件
T=100 - 110°C; 168 h; sealed tube;
参考文献
Chemical and Pharmaceutical Bulletin, , vol. 29, # 9 p. 2525 - 2530
反应条件
1.1: pyridine / 0.5 h / 20 - 100 °C / |Inert atmosphere 2.1: magnesium / diethyl ether / 0.17 h / |Inert atmosphere; |Reflux 2.2: 0.5 h / |Inert atmosphere; |Heating 3.1: FeCl3·6H2O / 4 h / 60 °C / |Inert atmosphere View Scheme
参考文献
Bunce, Richard A.; Cain, Nicholas R.; Cooper, John G.
Organic Preparations and Procedures International, 2013 , vol. 45, # 1 p. 28 - 43
