2-羟基-4-甲基-5-硝基吡啶合成路线

6635-90-12-甲氧基-4-甲基-5-硝基吡啶→21901-41-72-羟基-4-甲基-5-硝基吡啶

参考文献

Phenex Pharmaceuticals AG
Patent: EP1894924 A1, 2008 ;
Location in patent: Page/Page column 33 ;

21901-40-62-氨基-4-甲基-5-硝基吡啶→21901-41-72-羟基-4-甲基-5-硝基吡啶

参考文献

Beijing Yiling Bioengineering Co., Ltd.
Patent: EP2366691 A1, 2011 ;
Location in patent: Page/Page column 13 ;

695-34-12-氨基-4-甲基吡啶→21901-41-72-羟基-4-甲基-5-硝基吡啶

参考文献

Journal of the Chemical Society, , p. 2448,2455

695-34-12-氨基-4-甲基吡啶→21901-41-72-羟基-4-甲基-5-硝基吡啶+21901-18-82-羟基-3-硝基-4-甲基吡啶

参考文献

Journal of Fluorine Chemistry, , vol. 132, # 8 p. 541 - 547

21901-41-72-羟基-4-甲基-5-硝基吡啶→1049706-73-13-溴-2-氯-4-甲基-5-硝基吡啶

参考文献

Pryde, David C.; Webster, Rob; Butler, Scott L.; Murray, Edward J.; Whitby, Kevin; Pickford, Chris; Westby, Mike; Palmer, Michael J.; Bull, David J.; Vuong, Hannah; Blakemore, David C.; Stead, Darren; Ashcroft, Christopher; Gardner, Iain; Bru, Claire; Cheung, Wai-Yee; Roberts, Ieuan O.; Morton, Jennifer; Bissell, Richard A.
MedChemComm, 2013 , vol. 4, # 4 p. 709 - 719

21901-41-72-羟基-4-甲基-5-硝基吡啶→393-53-33-氟吡啶-4-甲酸

参考文献

Roe; Seligman
Journal of Organic Chemistry, 1955 , vol. 20, p. 1729,1731

21901-41-72-羟基-4-甲基-5-硝基吡啶→3430-27-13-氨基-4-甲基吡啶

参考文献

Roe; Seligman
Journal of Organic Chemistry, 1955 , vol. 20, p. 1729,1731

21901-41-72-羟基-4-甲基-5-硝基吡啶→907545-47-52-氯-5-硝基-4-吡啶羧酸

参考文献

Beijing Yiling Bioengineering Co., Ltd.
Patent: EP2366691 A1, 2011 ;

21901-41-72-羟基-4-甲基-5-硝基吡啶→399-88-23-氟-4-甲基吡啶

参考文献

Roe; Seligman
Journal of Organic Chemistry, 1955 , vol. 20, p. 1729,1731

21901-41-72-羟基-4-甲基-5-硝基吡啶→267876-19-71H-吡咯并[2,3-C]吡啶-5-甲胺

参考文献

Sanderson, Philip E. J.; Stanton, Matthew G.; Dorsey, Bruce D.; Lyle, Terry A.; McDonough, Colleen; Sanders, William M.; Savage, Kelly L.; Naylor-Olsen, Adel M.; Krueger, Julie A.; Lewis, S. Dale; Lucas, Bobby J.; Lynch, Joseph J.; Yan, Youwei
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 5 p. 795 - 798