2-氨基-3-硝基-6-甲基吡啶合成路线 （共 25 条）
反应条件
1: HCl, NaNO2 / Ambient temperature 2: 49 percent / dimethylformamide / 6 h / Heating View Scheme
参考文献
Troschutz; Karger
Journal of Heterocyclic Chemistry, 1996 , vol. 33, # 6 p. 1815 - 1821
反应条件
sulfuric acid in water
参考文献
Bristol-Myers Squibb Company
Patent: US6011029 A1, 2000 ;
反应条件
1: water; sodium nitrite; sulfuric acid / 16 h / 0 °C 2: trichlorophosphate / 4 h / Reflux 3: sodium dichromate; sulfuric acid / 40 h / 30 °C View Scheme
参考文献
Beijing Yiling Bioengineering Co., Ltd.
Patent: EP2366691 A1, 2011 ;
反应条件
nitric acid in conc. H2 SO4; sulfuric acid
参考文献
Merck and Co., Inc.
Patent: US5223499 A1, 1993 ;
US 5223499 A
反应条件
1: 38.5 percent / dimethylformamide / 16 h / 140 °C
2: 1.8 g / potassium carbonate; potassium permanganate / H2O; 2-methyl-propan-2-ol / 3 h
View Scheme
参考文献
Chand, Pooran; Kotian, Pravin L.; Morris, Philip E.; Bantia, Shanta; Walsh, David A.; Babu, Yarlagadda S.
Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 7 p. 2665 - 2678
