2-羟基-3-硝基-4-甲基吡啶合成路线 （共 16 条）
反应条件
sulfuric acid; water; sodium nitrite T=0°C; Reflux;
参考文献
Beijing Yiling Bioengineering Co., Ltd.
Patent: EP2366691 A1, 2011 ;
Location in patent: Page/Page column 7 ;
反应条件
1: With sulfuric acid; nitric acid 2: With hydrogenchloride; sodium nitrite
参考文献
Journal of Fluorine Chemistry, , vol. 132, # 8 p. 541 - 547
反应条件
1.1: nitric acid; sulfuric acid / 24 h / 0 - 50 °C 1.2: pH 7 / Cooling with ice 2.1: water; sodium nitrite; sulfuric acid / 0 °C / Reflux View Scheme
反应条件
1: phosphoryl chloride 2: acetic acid; sodium acetate; palladium/charcoal / Hydrogenation 3: ethyl nitrite; petroleum ether / Diazotization 4: KMnO4; H2O View Scheme
参考文献
Roe; Seligman
Journal of Organic Chemistry, 1955 , vol. 20, p. 1729,1731
反应条件
1: phosphorus (V)-chloride; phosphoryl chloride / 115 °C 2: copper-powder; benzoic acid / 150 °C 3: KMnO4; H2O View Scheme
参考文献
Brown
Journal of the American Chemical Society, 1954 , vol. 76, p. 3167
反应条件
1: phosphoryl chloride 2: acetic acid; sodium acetate; palladium/charcoal / Hydrogenation View Scheme
参考文献
Roe; Seligman
Journal of Organic Chemistry, 1955 , vol. 20, p. 1729,1731
反应条件
1: phosphorus (V)-chloride; phosphoryl chloride / 115 °C 2: copper-powder; benzoic acid / 150 °C View Scheme
参考文献
Journal of the American Chemical Society, , vol. 76, p. 3167
反应条件
1: phosphoryl chloride 2: acetic acid; sodium acetate; palladium/charcoal / Hydrogenation 3: ethyl nitrite; petroleum ether / Diazotization View Scheme
参考文献
Roe; Seligman
Journal of Organic Chemistry, 1955 , vol. 20, p. 1729,1731
反应条件
1.1: 87 percent / 4-dimethylaminopyridine / CH2Cl2 / 0 °C 2.1: 76 percent / triphenylphosphine / Pd(PPh3)4 / toluene / 3 h / Heating 3.1: O3 / methanol / -78 °C 3.2: 86 percent / Me2S / -78 - 20 °C View Scheme
参考文献
Li, Jun; Chen, Shu-Hui; Li, Xiuyan; Niu, Chuansheng; Doyle, Terrence W.
Tetrahedron, 1998 , vol. 54, # 3-4 p. 393 - 400
反应条件
1: phosphoryl chloride 2: acetic acid; sodium acetate; palladium/charcoal / Hydrogenation 3: ethyl nitrite; petroleum ether / Diazotization 4: KMnO4; H2O 5: SOCl2 / Erwaermen des Reaktionsgemisches mit Aethanol View Scheme
参考文献
Roe; Seligman
Journal of Organic Chemistry, 1955 , vol. 20, p. 1729,1731
