2,2,2-三氯-1-(1-甲基-1H-吡咯-2-基)-乙酮合成路线 （共 32 条）
反应条件
1: HNO3, Ac2O / -40 - 20 °C
2: 47 percent / NaOMe / 2 h / Ambient temperature
3: H2 / 10percent Pd/C / ethyl acetate / 48 h / 836 Torr
View Scheme
参考文献
Badaea, Concepcion; Souard, Florence; Vicent, Cristina
Journal of Organic Chemistry, 2012 , vol. 77, # 23 p. 10870 - 10881
反应条件
1: HNO3; H2SO4 / acetic anhydride
2: 94.6 percent / 2-methyl-propan-2-ol / 5 h / Heating
View Scheme
参考文献
Wurtz, Nicholas R.; Turner, James M.; Baird, Eldon E.; Dervan, Peter B.
Organic Letters, 2001 , vol. 3, # 8 p. 1201 - 1203
反应条件
1: 1,4-dioxane / 24 h / 80 °C
2: trifluoroacetic acid / 12 h / 20 - 50 °C
3: trichlorophosphate / 2 h / 100 °C
4: sodium carbonate; palladium 10 on activated carbon; hydrogen / methanol / 12 h / 20 °C / 760.05 Torr
View Scheme
参考文献
Nechayev, Maxim A.; Gorobets, Nikolay Yu.; Kovalenko, Sergiy M.; Tolmachev, Andrey A.
Synthesis (Germany), 2013 , vol. 45, # 7 art. no. SS-2012-T0878-OP, p. 919 - 924
反应条件
phenyl-magnesium bromide in tetrahydrofuran
T=20°C; 1 h; Inert atmosphere; Reagent/catalyst;
参考文献
Essa, Ali H.; Lerrick, Reinner I.; Tuna, Floriana; Harrington, Ross W.; Clegg, William; Hall, Michael J.
Chemical Communications, 2013 , vol. 49, # 27 p. 2756 - 2758
反应条件
in tetrahydrofuran
T=20°C; 1 h; Inert atmosphere;
参考文献
Essa, Ali H.; Lerrick, Reinner I.; Tuna, Floriana; Harrington, Ross W.; Clegg, William; Hall, Michael J.
Chemical Communications, 2013 , vol. 49, # 27 p. 2756 - 2758
反应条件
in tetrahydrofuran
T=20°C; 1 h; Inert atmosphere;
参考文献
Essa, Ali H.; Lerrick, Reinner I.; Tuna, Floriana; Harrington, Ross W.; Clegg, William; Hall, Michael J.
Chemical Communications, 2013 , vol. 49, # 27 p. 2756 - 2758
反应条件
in tetrahydrofuran
T=20°C; 1 h;
参考文献
Essa, Ali H.; Lerrick, Reinner I.; Tuna, Floriana; Harrington, Ross W.; Clegg, William; Hall, Michael J.
Chemical Communications, 2013 , vol. 49, # 27 p. 2756 - 2758
反应条件
in tetrahydrofuran
T=20°C; 1 h; Inert atmosphere;
参考文献
Essa, Ali H.; Lerrick, Reinner I.; Tuna, Floriana; Harrington, Ross W.; Clegg, William; Hall, Michael J.
Chemical Communications, 2013 , vol. 49, # 27 p. 2756 - 2758
反应条件
in tetrahydrofuran
T=20°C; 1 h;
参考文献
Essa, Ali H.; Lerrick, Reinner I.; Tuna, Floriana; Harrington, Ross W.; Clegg, William; Hall, Michael J.
Chemical Communications, 2013 , vol. 49, # 27 p. 2756 - 2758
反应条件
in tetrahydrofuran
T=20°C; 1 h;
参考文献
Essa, Ali H.; Lerrick, Reinner I.; Tuna, Floriana; Harrington, Ross W.; Clegg, William; Hall, Michael J.
Chemical Communications, 2013 , vol. 49, # 27 p. 2756 - 2758
