3-甲基-2-苯并恶唑酮合成路线 （共 63 条）
反应条件
1: 3H-benzoxazol-2-one With sodium hydride in tetrahydrofuran T=0°C; 0.5 h; 2: methyl iodide in tetrahydrofuran T=20°C; 6 h;
参考文献
MEMORY PHARMACEUTICALS CORPORATION; DANCA, Mihaela, Diana; DUNN, Robert; TEHIM, Ashok; XIE, Wenge
Patent: WO2010/21797 A1, 2010 ;
Location in patent: Page/Page column 88 ;
WO 2010/021797 A1
反应条件
sodium hydroxide in water T=70 - 80°C; 1 h;
参考文献
Baytas, Sultan; Turan Dural, Niludie Nermin; Oezkan, Yesim; Simsek, Hasan Bolkan; Guersel, Tuerkiz; Uenlue, Serdar
Turkish Journal of Chemistry, 2012 , vol. 36, # 3 p. 367 - 382
反应条件
Neutral lead acetate T=199.85°C; 3 h;
参考文献
Fu, Yue; Baba, Toshihide; Ono, Yoshio
Journal of Catalysis, 2001 , vol. 197, # 1 p. 91 - 97
反应条件
potassium carbonate in N,N-dimethyl-formamide T=125°C; 2 h;
参考文献
Ucar, Huseyin; Van Derpoorten, Kim; Cacciaguerra, Silvia; Spampinato, Santi; Stables, James P.; Depovere, Paul; Isa, Majed; Masereel, Bernard; Delarge, Jacques; Poupaert, Jacques H.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 7 p. 1138 - 1145
反应条件
Neutral lead acetate T=-0.15°C; 0.5 h;
参考文献
Fu, Yue; Baba, Toshihide; Ono, Yoshio
Journal of Catalysis, 2001 , vol. 197, # 1 p. 91 - 97
参考文献
ZENECA LIMITED; ZENECA Pharma S.A.
Patent: EP462831 B1, 1996 ;
反应条件
sodium carbonate in chloroform; water 1 h; Ambient temperature;
参考文献
Chemistry of Natural Compounds, , vol. 16, # 4 p. 403 - 405
Khimiya Prirodnykh Soedinenii, , vol. 16, # 4 p. 553 - 556
反应条件
formaldehyd; sodium carbonate in chloroform; water 1 h; Ambient temperature;
参考文献
Chemistry of Natural Compounds, , vol. 16, # 4 p. 403 - 405
Khimiya Prirodnykh Soedinenii, , vol. 16, # 4 p. 553 - 556
反应条件
Neutral lead acetate T=199.85°C; 3 h;
参考文献
Journal of Catalysis, , vol. 197, # 1 p. 91 - 97
反应条件
1: cc. HCl / 1 h / Heating 2: NaOH / H2O / Ambient temperature View Scheme
参考文献
Tetrahedron, , vol. 42, # 14 p. 4073 - 4082
