triethylamine; 4-(N,N-dimethlyamino)pyridine in dichloromethane T=0 - 20°C; 2 - 3 h;

1: tert-butyl 3-(cyanomethyl)-1H-indole-1-carboxylate With sodium hydride in tetrahydrofuran; dimethyl sulfoxide T=0 - 20°C; 1 h; 2: methyl iodide in tetrahydrofuran; dimethyl sulfoxide T=20°C; 1 h;

sodium hydroxide in tetrahydrofuran; N,N-dimethyl-formamide T=0 - 20°C;

1: With potassium hydroxide in tert-butyl methyl ether; dimethyl sulfoxide T=20°C; 2 h; 2: With hydrogenchloride in water Product distribution / selectivity;