3,12-二氧代齐墩果-9(11)-烯-28-酸甲酯合成路线 （共 11 条）
反应条件
1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione in ethyl acetate 24 h; Inert atmosphereReflux;
参考文献
Fu, Liangfeng; Gribble, Gordon W.
Organic Letters, 2013 , vol. 15, # 7 p. 1622 - 1625
反应条件
1: 97 percent / methanolic KOH / 0.5 h / Heating 2: 92 percent / Jones reagent / acetone / 0.17 h / 20 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 43, # 22 p. 4233 - 4246
反应条件
1: pyridine 2: 30percent H2O2 / acetic acid 3: Br2, HBr / acetic acid 4: KOH / methanol 5: Jones reagent View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 13 p. 1623 - 1628
反应条件
1.1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 0 - 20 °C / |Inert atmosphere 2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 24 h / 0 - 20 °C / |Inert atmosphere 2.2: 24 h / 35 °C / |Inert atmosphere 3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 24 h / |Inert atmosphere; |Reflux View Scheme
参考文献
Organic Letters, , vol. 15, # 7 p. 1622 - 1625
反应条件
1: Br2, HBr / acetic acid 2: KOH / methanol 3: Jones reagent View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 13 p. 1623 - 1628
反应条件
1: 30percent H2O2 / acetic acid 2: Br2, HBr / acetic acid 3: KOH / methanol 4: Jones reagent View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 7, # 13 p. 1623 - 1628
反应条件
1: 99 percent / NaOMe / benzene / 2 h / 20 °C 2: 66 percent / NH2OH*HCl / ethanol; H2O / 1 h / Heating 3: 100 percent / NaOMe / methanol; diethyl ether / 0.75 h / 20 °C 4: 92 percent / DDQ / benzene / 0.5 h / Heating 5: 68 percent / LiI / dimethylformamide / 4 h / Heating View Scheme
参考文献
Honda, Tadashi; Rounds, BarbieAnn V.; Gribble, Gordon W.; Suh, Nanjoo; Wang, Yongping; Sporn, Michael B.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 19 p. 2711 - 2714
反应条件
1: 99 percent / NaOMe / benzene / 2 h / 20 °C 2: 66 percent / NH2OH*HCl / ethanol; H2O / 1 h / Heating 3: 100 percent / NaOMe / methanol; diethyl ether / 0.75 h / 20 °C 4: 92 percent / DDQ / benzene / 0.5 h / Heating View Scheme
参考文献
Honda, Tadashi; Rounds, BarbieAnn V.; Gribble, Gordon W.; Suh, Nanjoo; Wang, Yongping; Sporn, Michael B.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 19 p. 2711 - 2714
反应条件
1: 99 percent / NaOMe / benzene / 2 h / 20 °C 2: 66 percent / NH2OH*HCl / ethanol; H2O / 1 h / Heating 3: 100 percent / NaOMe / methanol; diethyl ether / 0.75 h / 20 °C View Scheme
参考文献
Honda; Rounds; Bore; Finlay; Favaloro Jr.; Suh; Wang; Sporn; Gribble
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4233 - 4246
反应条件
sodium methylate in benzene T=20°C; 2 h;
参考文献
Honda; Rounds; Bore; Finlay; Favaloro Jr.; Suh; Wang; Sporn; Gribble
Journal of Medicinal Chemistry, 2000 , vol. 43, # 22 p. 4233 - 4246
