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63148-62-9
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
文多灵
合成路线
（共 50 条）
867214-27-5
→
反应条件
2182-14-1
文多灵
反应条件
triphenylphosphine; diethylazodicarboxylate in tetrahydrofuran T=20°C; 24 h;
参考文献
Sasaki, Yoshikazu; Kato, Daisuke; Boger, Dale L.
Journal of the American Chemical Society, 2010 , vol. 132, # 38 p. 13533 - 13544
108-24-7
乙酸酐
+
3633-92-9
脱乙酰基文多灵
→
反应条件
2182-14-1
文多灵
反应条件
sodium acetate T=20°C; Acetylation; 4 h;
参考文献
Kobayashi, Satoshi; Ueda, Toshihiro; Fukuyama, Tohru
Synlett, 2000 , # 6 p. 883 - 886
202807-44-1
6-甲氧基-1-甲基-1H-吲哚-3-甲醛
→
反应条件
2182-14-1
文多灵
反应条件
1.1: 99 percent / NH4OAc / 1 h / Heating 2.1: 96 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating 3.1: ethanol / 25 °C 3.2: 64 percent / N2H4*H2O / ethanol / 5 h / Heating 4.1: 61 percent / EDCI; DMAP / CH2Cl2 / 19 h / 25 °C 5.1: 67 percent / p-toluenesulfonyl chloride; Et3N / CH2Cl2 / 20 h / 25 °C 6.1: 96 percent / EDCI; DMAP / CH2Cl2 / 16 h / 0 - 25 °C 7.1: 53 percent / various solvent(s) / 90 h / 230 °C 8.1: Chiracel OD / propan-2-ol; hexane 9.1: LDA; bis(trimethylsilyl)peroxide / tetrahydrofuran / 4 h / -40 °C 9.2: 64 percent / tetrahydrofuran / 2 h / -40 - 20 °C 10.1: 70 percent / Lawesson's reagent / toluene / 3 h / 110 °C 11.1: 91 percent / Raney-Ni; H2 / tetrahydrofuran / 15 h / 20 °C 12.1: 97 percent / NaOAc / 17 h / 20 °C 13.1: 98 percent / H2 / PtO2 / methanol; ethyl acetate / 3 h / 2068.59 - 2327.17 Torr 14.1: 89 percent / Bu4NF / tetrahydrofuran / 0.5 h / 20 °C 15.1: 75 percent / DEAD; PPh3 / tetrahydrofuran / 24 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 20 p. 4539 - 4542
1968-17-8
→
反应条件
2182-14-1
文多灵
反应条件
1.1: POCl3 / 0.75 h / 35 °C 1.2: 99 percent / aq. NaOH / dimethylformamide / 0.17 h / Heating 2.1: 99 percent / NH4OAc / 1 h / Heating 3.1: 96 percent / LiAlH4 / tetrahydrofuran / 2 h / Heating 4.1: ethanol / 25 °C 4.2: 64 percent / N2H4*H2O / ethanol / 5 h / Heating 5.1: 61 percent / EDCI; DMAP / CH2Cl2 / 19 h / 25 °C 6.1: 67 percent / p-toluenesulfonyl chloride; Et3N / CH2Cl2 / 20 h / 25 °C 7.1: 96 percent / EDCI; DMAP / CH2Cl2 / 16 h / 0 - 25 °C 8.1: 53 percent / various solvent(s) / 90 h / 230 °C 9.1: Chiracel OD / propan-2-ol; hexane 10.1: LDA; bis(trimethylsilyl)peroxide / tetrahydrofuran / 4 h / -40 °C 10.2: 64 percent / tetrahydrofuran / 2 h / -40 - 20 °C 11.1: 70 percent / Lawesson's reagent / toluene / 3 h / 110 °C 12.1: 91 percent / Raney-Ni; H2 / tetrahydrofuran / 15 h / 20 °C 13.1: 97 percent / NaOAc / 17 h / 20 °C 14.1: 98 percent / H2 / PtO2 / methanol; ethyl acetate / 3 h / 2068.59 - 2327.17 Torr 15.1: 89 percent / Bu4NF / tetrahydrofuran / 0.5 h / 20 °C 16.1: 75 percent / DEAD; PPh3 / tetrahydrofuran / 24 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 20 p. 4539 - 4542
64954-92-3
→
反应条件
2182-14-1
文多灵
反应条件
1.1: ethanol / 25 °C 1.2: 64 percent / N2H4*H2O / ethanol / 5 h / Heating 2.1: 61 percent / EDCI; DMAP / CH2Cl2 / 19 h / 25 °C 3.1: 67 percent / p-toluenesulfonyl chloride; Et3N / CH2Cl2 / 20 h / 25 °C 4.1: 96 percent / EDCI; DMAP / CH2Cl2 / 16 h / 0 - 25 °C 5.1: 53 percent / various solvent(s) / 90 h / 230 °C 6.1: Chiracel OD / propan-2-ol; hexane 7.1: LDA; bis(trimethylsilyl)peroxide / tetrahydrofuran / 4 h / -40 °C 7.2: 64 percent / tetrahydrofuran / 2 h / -40 - 20 °C 8.1: 70 percent / Lawesson's reagent / toluene / 3 h / 110 °C 9.1: 91 percent / Raney-Ni; H2 / tetrahydrofuran / 15 h / 20 °C 10.1: 97 percent / NaOAc / 17 h / 20 °C 11.1: 98 percent / H2 / PtO2 / methanol; ethyl acetate / 3 h / 2068.59 - 2327.17 Torr 12.1: 89 percent / Bu4NF / tetrahydrofuran / 0.5 h / 20 °C 13.1: 75 percent / DEAD; PPh3 / tetrahydrofuran / 24 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 20 p. 4539 - 4542
867214-12-8
→
反应条件
2182-14-1
文多灵
反应条件
1.1: 79 percent / AcOH / tetrahydrofuran / 35 °C 2.1: 67 percent / p-toluenesulfonyl chloride; Et3N / CH2Cl2 / 20 h / 25 °C 3.1: 96 percent / EDCI; DMAP / CH2Cl2 / 16 h / 0 - 25 °C 4.1: 53 percent / various solvent(s) / 90 h / 230 °C 5.1: Chiracel OD / propan-2-ol; hexane 6.1: LDA; bis(trimethylsilyl)peroxide / tetrahydrofuran / 4 h / -40 °C 6.2: 64 percent / tetrahydrofuran / 2 h / -40 - 20 °C 7.1: 70 percent / Lawesson's reagent / toluene / 3 h / 110 °C 8.1: 91 percent / Raney-Ni; H2 / tetrahydrofuran / 15 h / 20 °C 9.1: 97 percent / NaOAc / 17 h / 20 °C 10.1: 98 percent / H2 / PtO2 / methanol; ethyl acetate / 3 h / 2068.59 - 2327.17 Torr 11.1: 89 percent / Bu4NF / tetrahydrofuran / 0.5 h / 20 °C 12.1: 75 percent / DEAD; PPh3 / tetrahydrofuran / 24 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 20 p. 4539 - 4542
867214-10-6
→
反应条件
2182-14-1
文多灵
反应条件
1.1: 61 percent / EDCI; DMAP / CH2Cl2 / 19 h / 25 °C 2.1: 67 percent / p-toluenesulfonyl chloride; Et3N / CH2Cl2 / 20 h / 25 °C 3.1: 96 percent / EDCI; DMAP / CH2Cl2 / 16 h / 0 - 25 °C 4.1: 53 percent / various solvent(s) / 90 h / 230 °C 5.1: Chiracel OD / propan-2-ol; hexane 6.1: LDA; bis(trimethylsilyl)peroxide / tetrahydrofuran / 4 h / -40 °C 6.2: 64 percent / tetrahydrofuran / 2 h / -40 - 20 °C 7.1: 70 percent / Lawesson's reagent / toluene / 3 h / 110 °C 8.1: 91 percent / Raney-Ni; H2 / tetrahydrofuran / 15 h / 20 °C 9.1: 97 percent / NaOAc / 17 h / 20 °C 10.1: 98 percent / H2 / PtO2 / methanol; ethyl acetate / 3 h / 2068.59 - 2327.17 Torr 11.1: 89 percent / Bu4NF / tetrahydrofuran / 0.5 h / 20 °C 12.1: 75 percent / DEAD; PPh3 / tetrahydrofuran / 24 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 20 p. 4539 - 4542
867214-15-1
→
反应条件
2182-14-1
文多灵
反应条件
1.1: 96 percent / EDCI; DMAP / CH2Cl2 / 16 h / 0 - 25 °C 2.1: 53 percent / various solvent(s) / 90 h / 230 °C 3.1: Chiracel OD / propan-2-ol; hexane 4.1: LDA; bis(trimethylsilyl)peroxide / tetrahydrofuran / 4 h / -40 °C 4.2: 64 percent / tetrahydrofuran / 2 h / -40 - 20 °C 5.1: 70 percent / Lawesson's reagent / toluene / 3 h / 110 °C 6.1: 91 percent / Raney-Ni; H2 / tetrahydrofuran / 15 h / 20 °C 7.1: 97 percent / NaOAc / 17 h / 20 °C 8.1: 98 percent / H2 / PtO2 / methanol; ethyl acetate / 3 h / 2068.59 - 2327.17 Torr 9.1: 89 percent / Bu4NF / tetrahydrofuran / 0.5 h / 20 °C 10.1: 75 percent / DEAD; PPh3 / tetrahydrofuran / 24 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 20 p. 4539 - 4542
867214-13-9
→
反应条件
2182-14-1
文多灵
反应条件
1.1: 67 percent / p-toluenesulfonyl chloride; Et3N / CH2Cl2 / 20 h / 25 °C 2.1: 96 percent / EDCI; DMAP / CH2Cl2 / 16 h / 0 - 25 °C 3.1: 53 percent / various solvent(s) / 90 h / 230 °C 4.1: Chiracel OD / propan-2-ol; hexane 5.1: LDA; bis(trimethylsilyl)peroxide / tetrahydrofuran / 4 h / -40 °C 5.2: 64 percent / tetrahydrofuran / 2 h / -40 - 20 °C 6.1: 70 percent / Lawesson's reagent / toluene / 3 h / 110 °C 7.1: 91 percent / Raney-Ni; H2 / tetrahydrofuran / 15 h / 20 °C 8.1: 97 percent / NaOAc / 17 h / 20 °C 9.1: 98 percent / H2 / PtO2 / methanol; ethyl acetate / 3 h / 2068.59 - 2327.17 Torr 10.1: 89 percent / Bu4NF / tetrahydrofuran / 0.5 h / 20 °C 11.1: 75 percent / DEAD; PPh3 / tetrahydrofuran / 24 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 20 p. 4539 - 4542
867214-04-8
→
反应条件
2182-14-1
文多灵
反应条件
1.1: 53 percent / various solvent(s) / 90 h / 230 °C 2.1: Chiracel OD / propan-2-ol; hexane 3.1: LDA; bis(trimethylsilyl)peroxide / tetrahydrofuran / 4 h / -40 °C 3.2: 64 percent / tetrahydrofuran / 2 h / -40 - 20 °C 4.1: 70 percent / Lawesson's reagent / toluene / 3 h / 110 °C 5.1: 91 percent / Raney-Ni; H2 / tetrahydrofuran / 15 h / 20 °C 6.1: 97 percent / NaOAc / 17 h / 20 °C 7.1: 98 percent / H2 / PtO2 / methanol; ethyl acetate / 3 h / 2068.59 - 2327.17 Torr 8.1: 89 percent / Bu4NF / tetrahydrofuran / 0.5 h / 20 °C 9.1: 75 percent / DEAD; PPh3 / tetrahydrofuran / 24 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 7, # 20 p. 4539 - 4542
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