2-甲基-2-苯基丙烷-1-醇合成路线 （共 48 条）
参考文献
Haller; Ramart
Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1922 , vol. 174, p. 1212
反应条件
2: NO2/HNO3, Ac2O 3: pyridine View Scheme
参考文献
Tanida,H. et al.
Journal of Organic Chemistry, 1969 , vol. 34, p. 1086 - 1089
参考文献
Fainberg; Winstein
Journal of the American Chemical Society, 1956 , vol. 78, p. 2767,2768
反应条件
2: NO2/HNO3, Ac2O 3: H2 / PtO2 View Scheme
参考文献
Tanida,H. et al.
Journal of Organic Chemistry, 1969 , vol. 34, p. 1086 - 1089
反应条件
1: 97 percent / Et3N; 4-pyrrolidinopyridine / 0.33 h / 20 °C 2: 63.5 percent / AlCl3 / CS2 / 1.5 h / 0 - 5 °C 3: 68 percent / p-TsOH*H2O / benzene / 24 h / Heating 4: 99 percent / NaOH; MeOH / 0.5 h / 20 °C 5: 89 percent / Jones reagent / acetone / 0 °C 6: 92 percent / diethyl ether / 0 °C 7: 89 percent / HCl; H2O / tetrahydrofuran / 15 h / 20 °C 8: 95 percent / NaBH4 / methanol; tetrahydrofuran / 0.5 h / 0 °C 9: 44 percent / K2CO3; KI / dimethylformamide; toluene / 7 h / Heating 10: 67.6 percent / NaOH; MeOH / 2 h / Heating View Scheme
参考文献
Di Giacomo, Barbara; Coletta, Donato; Natalini, Benedetto; Ni, Ming-Hong; Pellicciari, Roberto
Farmaco, 1999 , vol. 54, # 9 p. 600 - 610
反应条件
pyridine T=0 - 20°C; 2 h;
参考文献
CIPLA LIMITED; WAIN, Christopher, Paul
Patent: WO2005/19175 A1, 2005 ;
Location in patent: Page/Page column 24 ;
反应条件
1: With 2,2,6,6-tetramethyl-1-piperidinyloxy, free radical; 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione in dichloromethane T=20°C; 2 h; Inert atmosphere; 2: With ammonia; iodine in dichloromethane; water T=20°C; 3 h; Inert atmosphere;
参考文献
Synthesis (Germany), , vol. 45, # 15 art. no. SS-2013-F0311-OP, p. 2155 - 2164
反应条件
1: 97 percent / Et3N; 4-pyrrolidinopyridine / 0.33 h / 20 °C 2: 63.5 percent / AlCl3 / CS2 / 1.5 h / 0 - 5 °C 3: 68 percent / p-TsOH*H2O / benzene / 24 h / Heating 4: 99 percent / NaOH; MeOH / 0.5 h / 20 °C 5: 89 percent / Jones reagent / acetone / 0 °C 6: 92 percent / diethyl ether / 0 °C 7: 89 percent / HCl; H2O / tetrahydrofuran / 15 h / 20 °C View Scheme
参考文献
Di Giacomo, Barbara; Coletta, Donato; Natalini, Benedetto; Ni, Ming-Hong; Pellicciari, Roberto
Farmaco, 1999 , vol. 54, # 9 p. 600 - 610
反应条件
1: 97 percent / Et3N; 4-pyrrolidinopyridine / 0.33 h / 20 °C 2: 63.5 percent / AlCl3 / CS2 / 1.5 h / 0 - 5 °C 3: 68 percent / p-TsOH*H2O / benzene / 24 h / Heating 4: 99 percent / NaOH; MeOH / 0.5 h / 20 °C 5: 89 percent / Jones reagent / acetone / 0 °C 6: 92 percent / diethyl ether / 0 °C 7: 89 percent / HCl; H2O / tetrahydrofuran / 15 h / 20 °C 8: 95 percent / NaBH4 / methanol; tetrahydrofuran / 0.5 h / 0 °C 9: 44 percent / K2CO3; KI / dimethylformamide; toluene / 7 h / Heating View Scheme
参考文献
Di Giacomo, Barbara; Coletta, Donato; Natalini, Benedetto; Ni, Ming-Hong; Pellicciari, Roberto
Farmaco, 1999 , vol. 54, # 9 p. 600 - 610
反应条件
1: 97 percent / Et3N; 4-pyrrolidinopyridine / 0.33 h / 20 °C 2: 63.5 percent / AlCl3 / CS2 / 1.5 h / 0 - 5 °C View Scheme
参考文献
Yu, Zhoujie; Wang, Wei; Chen, Liqin
Journal of Labelled Compounds and Radiopharmaceuticals, 2011 , vol. 54, # 7 p. 352 - 356
