6-氮杂尿苷-2,3,5-三乙酸酯合成路线 （共 5 条）
反应条件
pyridine; 4-(N,N-dimethlyamino)pyridine T=20°C; 2 h;
参考文献
Journal of the American Chemical Society, , vol. 122, # 42 p. 10259 - 10267
参考文献
Tetrahedron Letters, , vol. 36, # 43 p. 7845 - 7848
反应条件
sodium methylate in methanol T=0°C; 0.25 h;
参考文献
Depelley, Jean; Granet, Robert; Kaouadji, Mourad; Krausz, Pierre; Piekarski, Salomon; Delebassee, Sylvie; Bosgiraud, Claudine
Nucleosides and Nucleotides, 1996 , vol. 15, # 5 p. 995 - 1008
反应条件
T=36.8 - 90°C; Hydrolysis; pH=2.0 - 7.0; Kinetics; Further Variations:pH-valuesTemperatures;
参考文献
Riley; Mummert; Zhou; Schowen; Vander Velde; Morton; Slavik
Pharmaceutical Research, 1995 , vol. 12, # 9 p. 1361 - 1370
反应条件
1.1: phosphorus oxychloride; triethylamine / acetonitrile / 0.5 h / 0 °C 1.2: acetonitrile / 4 h / 0 - 20 °C 2.1: 226 mg / NH4Cl; DBU / pyridine / 24 h / 20 °C 3.1: NH3 / methanol / 24 h / 20 °C View Scheme
参考文献
Oyelere; Strobel
Journal of the American Chemical Society, 2000 , vol. 122, # 42 p. 10259 - 10267
