3-环戊烯-1,1-二甲酸二乙酯合成路线 （共 19 条）
反应条件
hydrogen; dichlorobis(tricyclohexylphosphine)(benzylidene)rhodium in 1,2-dichloro-ethane T=70°C; P=760.051 Torr;
参考文献
Louie; Bielawski; Grubbs
Journal of the American Chemical Society, 2001 , vol. 123, # 45 p. 11312 - 11313
反应条件
1: KOH / H2O; ethanol / 6 h / Heating 2: 180 °C View Scheme
参考文献
Hosomi; Mikami; Sakurai
Bulletin of the Chemical Society of Japan, 1983 , vol. 56, # 9 p. 2784 - 2794
反应条件
1: KOH / H2O; ethanol / 6 h / Heating 2: 180 °C 3: 79 percent / LiAlH4 / diethyl ether View Scheme
参考文献
Bulletin of the Chemical Society of Japan, , vol. 56, # 9 p. 2784 - 2794
反应条件
1: With HgOAC in tetrahydrofuran; water T=20°C; 0.166667 h; 2: With perchloric acid in tetrahydrofuran; water 0.5 h; 3: With sodium hydroxide; sodium tetrahydroborate in tetrahydrofuran; water T=5°C; 1.25 h;
参考文献
BIOPROJET; Sun Pharmaceuticals Industries Ltd.
Patent: EP1650186 A1, 2006 ;
Location in patent: Page/Page column 13 ;
EP 1650186 A1
反应条件
sodium cyanide in dimethyl sulfoxide T=160°C; 6 h;
参考文献
Nugent, William A.; Feldman, Jerald; Calabrese, Joseph C.
Journal of the American Chemical Society, 1995 , vol. 117, # 35 p. 8992 - 8998
反应条件
pig liver esterase; water; sodium chloride T=20°C; 25 h; Enzymatic reaction;
参考文献
Tenbrink, Katharina; Sessler, Miriam; Schatz, Juergen; Groeger, Harald
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 13 p. 2363 - 2367
反应条件
pig liver esterase; water; sodium chloride T=20°C; 42 h; Enzymatic reaction;
参考文献
Tenbrink, Katharina; Sessler, Miriam; Schatz, Juergen; Groeger, Harald
Advanced Synthesis and Catalysis, 2011 , vol. 353, # 13 p. 2363 - 2367
反应条件
1: 65.7 percent / KOH / ethanol / 20 h / Ambient temperature
2: 89.4 percent / SOCl2 / toluene / 2 h / Heating
3: NaN3 / H2O; acetone / 0.5 h / 0 °C
4: benzene / 0.5 h / Heating
View Scheme
参考文献
Paulsen, Hans; Maass, Uwe
Chemische Berichte, 1981 , vol. 114, # 1 p. 346 - 358
反应条件
lithium aluminium tetrahydride in tetrahydrofuran
T=0°C; 4 h;
参考文献
Cipollina, Joseph A.; Ruediger, Edward H.; New, James S.; Wire, Mary E.; Shepherd, Timothy A.; et al.
Journal of Medicinal Chemistry, 1991 , vol. 34, # 11 p. 3316 - 3328
反应条件
potassium hydroxide in ethanol
20 h; Ambient temperature;
参考文献
Paulsen, Hans; Maass, Uwe
Chemische Berichte, 1981 , vol. 114, # 1 p. 346 - 358
