3-硝基-2-羧基苯甲酸甲酯合成路线 （共 25 条）
反应条件
thionyl chloride T=5°C; 20 - 25 h; Heating / reflux;
参考文献
DR. REDDY'S LABORATORIES LTD.; DR. REDDY'S LABORATORIES, INC.
Patent: WO2006/15134 A1, 2006 ;
Location in patent: Page/Page column 13 ;
反应条件
sulfuric acid in methanol T=59 - 65°C; 15 - 20 h; Heating / refluxIndustry scale;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1420016 A1, 2004 ;
Location in patent: Page 17 ;
参考文献
Chemische Berichte, , vol. 35, p. 3877,3879
参考文献
Chemische Berichte, , vol. 35, p. 3877,3879
参考文献
Chemische Berichte, , vol. 35, p. 3877,3879
Journal of the Chemical Society, , vol. 79, p. 1137
参考文献
Chemische Berichte, , vol. 35, p. 3877,3879
反应条件
anschliessend Behandeln mit wss. NaHCO3; Kinetics;
参考文献
Journal of the Chemical Society, , p. 553,566
参考文献
Chemische Berichte, , vol. 35, p. 3877,3879
反应条件
hydrogen; palladium on activated charcoal in methanol P=2068.6 Torr; 8 h; Ambient temperature;
参考文献
Rogers, Miriam E.; Averill, Bruce A.
Journal of Organic Chemistry, 1986 , vol. 51, # 17 p. 3308 - 3314
反应条件
1: 2-methoxycarbonyl-6-nitrobenzoic acid; triethylamine With diphenyl phosphoryl azide in DMF (N,N-dimethyl-formamide) T=20 - 35°C; 3 h; Industry scale; 2: tert-butyl alcohol in DMF (N,N-dimethyl-formamide) T=85 - 90°C; 4 - 7 h; Heating / reflux;
参考文献
Takeda Chemical Industries, Ltd.
Patent: EP1420016 A1, 2004 ;
Location in patent: Page 31-32 ;
