6-硝基噁唑并[4,5-b]吡啶-2(3h)-酮合成路线 （共 3 条）
反应条件
sulfuric acid; nitric acid T=-5 - 20°C; 60 h;
参考文献
MEMORY PHARMACEUTICALS CORPORATION; SCHUMACHER, Richard, A.; TEHIM, Ashok; XIE, Wenge
Patent: WO2010/24980 A1, 2010 ;
Location in patent: Page/Page column 103 ;
反应条件
1: Py / 1 h / Ambient temperature 2: HNO3, H2SO4 View Scheme
参考文献
Ruefenacht,K. et al.
Helvetica Chimica Acta, 1976 , vol. 59, p. 1593 - 1612
反应条件
1: With sodium hydroxide; water in ethanol
T=80°C; 3 h;
2: With hydrogenchloride; sodium carbonate in ethanol; water
pH=8;
参考文献
MEMORY PHARMACEUTICALS CORPORATION; SCHUMACHER, Richard, A.; TEHIM, Ashok; XIE, Wenge
Patent: WO2010/24980 A1, 2010 ;
Location in patent: Page/Page column 103; 104 ;
