N-(3-溴苯乙基)-2,2,2-三氟乙酰胺合成路线 （共 7 条）
反应条件
2,6-dimethylpyridine in dichloromethane T=0 - 20°C;
参考文献
ABBOTT LABORATORIES
Patent: WO2009/39134 A1, 2009 ;
Location in patent: Page/Page column 179 ;
反应条件
2,6-dimethylpyridine in dichloromethane T=0 - 20°C; 16 h;
参考文献
ASTRAZENECA AB
Patent: WO2004/60882 A1, 2004 ;
Location in patent: Page 30 ;
WO 2004/060882 A1
反应条件
sulfuric acid in acetic acid T=20°C; 72 h;
参考文献
Millennium Pharmaceuticals, Inc.
Patent: US2008/171754 A1, 2008 ;
Location in patent: Page/Page column 102 ;
US 20080171754 A1
反应条件
formaldehyd; sulfuric acid in water T=20°C; 16 h;
参考文献
NOVARTIS AG
Patent: WO2008/76954 A2, 2008 ;
Location in patent: Page/Page column 50 ;
WO 2008/076954 A2
反应条件
sulfuric acid; acetic acid T=0 - 20°C; 16.5 h;
参考文献
MERCK SERONO S.A.; QUATTROPANI, Anna; BAKER-GLENN, Charles; BLACKABY, Wesley; KNIGHT, Chris
Patent: WO2010/142628 A1, 2010 ;
Location in patent: Page/Page column 158 ;
WO 2010/142628 A1
反应条件
sulfuric acid in acetic acid
T=20°C; 72 h;
参考文献
Chytil, Milan; Engel, Sharon R.; Fang, Qun Kevin; Spear, Kerry L.
Patent: US2010/204214 A1, 2010 ;
Location in patent: Page/Page column 110-111 ;
反应条件
formaldehyd; sulfuric acid in water
T=20°C; 16 h;
参考文献
NOVARTIS AG
Patent: WO2008/76954 A2, 2008 ;
Location in patent: Page/Page column 50 ;
WO 2008/076954 A2
