2,4-二羟基苯甲酸甲酯合成路线 （共 80 条）
参考文献
Merck Patent Gesellschaft mit Beschrankter Haftung
Patent: US4477454 A1, 1984 ;
反应条件
1: 58 percent / K2CO3 / acetone
2: 96 percent / NaH / dimethylformamide
3: 86 percent / H2, AcOH / Pd/C / methanol
4: 95 percent / aq. NaOH / methanol
View Scheme
参考文献
Kuo, Michelle S.; Bock, Mark G.; Freidinger, Roger M.; Guidotti, Maribeth T.; Lis, Edward V.; Pawluczyk, Joseph M.; Perlow, Debra S.; Pettibone, Douglas J.; Quigley, Amy G.; Reiss, Duane R.; Williams, Peter D.; Woyden, Carla J.
Bioorganic and Medicinal Chemistry Letters, 1998 , vol. 8, # 21 p. 3081 - 3086
反应条件
1: 35 percent / HNO3; Ac2O / acetic acid / 0 - 22 °C
2: 98 percent / NaI; DIPEA / 1,2-dimethoxy-ethane; dimethylformamide / 1 h / 55 °C
3: 100 percent / H2 / Pd/C / ethyl acetate / 16 h
View Scheme
参考文献
Fisher, Martin; Basak, Ramkrishna; Kalverda, Arnout P.; Fishwick, Colin W. G.; Bruce Turnbull; Nelson, Adam
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 3 p. 486 - 494
反应条件
nitric acid; acetic anhydride in acetic acid
T=0 - 22°C;
参考文献
Heretsch, Philipp; Giannis, Athanassios
Synthesis, 2007 , # 17 p. 2614 - 2616
反应条件
1: aluminium chloride; diethyl ether / Einleiten von Chlorwasserstoff und anschliessendes Erwaermen mit Wasser
2: ethanol; amalgamated zinc; aqueous hydrochloric acid
3: aq. NaOH solution
View Scheme
参考文献
Shah; Laiwalla
Journal of the Chemical Society, 1938 , p. 1828,1831
反应条件
1: AlCl3; nitrobenzene / Erwaermen des Reaktionsprodukts mit wss. KOH
2: copper; quinoline
View Scheme
参考文献
Whalley
Journal of the Chemical Society, 1957 , p. 1833,1834
反应条件
in diphenylether
34 h; Heating;
参考文献
Patel, G. N.; Trivedi, K. N.
Synthetic Communications, 1989 , vol. 19, # 9-10 p. 1641 - 1648
反应条件
1: aqueous sulfuric acid
2: aq. NaOH solution
3: aqueous hydrochloric acid
View Scheme
参考文献
Sethna; Shah
Journal of the Indian Chemical Society, 1938 , vol. 15, p. 383,387
反应条件
1: sodium; benzene / anschliessend mit 4-Brom-2-methyl-buten-(2) erwaermen
2: aq. NaOH solution
View Scheme
参考文献
Schamschurin
Zhurnal Obshchei Khimii, 1949 , vol. 19, p. 1964,1967
Chem.Abstr., 1950 , p. 1974
反应条件
sodium; benzene
anschliessend mit 4-Brom-2-methyl-buten-(2) erwaermen;
参考文献
Bhandari, Prabha; Crombie, Leslie; Harper, Mark F.; Rossiter, John T.; Sanders, Mark; Whiting, Donald A.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 13 p. 1685 - 1698
