President and Fellows of Harvard College; Xie, Xiaoliang Sunney; Sims, Peter A.; Greenleaf, William J.; Duan, Haifeng
Patent: US2013/53252 A1, 2013 ;
Location in patent: Page/Page column ;
1.1: potassium carbonate / acetone / 1 h / 20 °C 1.2: 3 h 2.1: bromine / chloroform / 0.5 h / 0 - 20 °C 3.1: potassium tert-butylate / tetrahydrofuran / 0.5 h / 0 °C 3.2: 72 h / 20 °C View Scheme
参考文献
Huber, John D.; Bentzien, Joerg; Boyer, Stephen J.; Burke, Jennifer; De Lombaert, Stephane; Eickmeier, Christian; Guo, Xin; Haist, James V.; Hickey, Eugene R.; Kaplita, Paul; Karmazyn, Morris; Kemper, Raymond; Kennedy, Charles A.; Kirrane, Thomas; Madwed, Jeffrey B.; Mainolfi, Elizabeth; Nagaraja, Nelamangara; Soleymanzadeh, Fariba; Swinamer, Alan; Eldrup, Anne B.
Journal of Medicinal Chemistry, 2012 , vol. 55, # 16 p. 7114 - 7140
1.1: 33 percent / pyridine / CH2Cl2 / 48 h / 20 °C
2.1: K2CO3 / dimethylformamide
2.2: 76 percent / dimethylformamide / 1.5 h / 35 °C
3.1: 46 percent / K2CO3 / methanol / 3 h / 20 °C
View Scheme
参考文献
Bell, Ian M.; Erb, Jill M.; Freidinger, Roger M.; Gallicchio, Steven N.; Guare, James P.; Guidotti, Maribeth T.; Halpin, Rita A.; Hobbs, Doug W.; Homnick, Carl F.; Kuo, Michelle S.; Lis, Edward V.; Mathre, David J.; Michelson, Stuart R.; Pawluczy, Joseph M.; Pettibone, Douglas J.; Reiss, Duane R.; Vickers, Stanley; Williams, Peter D.; Woyden, Carla J.
Journal of Medicinal Chemistry, 1998 , vol. 41, # 12 p. 2146 - 2163
