3,5-二羟基苯甲酸甲酯合成路线 （共 124 条）
反应条件
bromine in chloroform; acetonitrile
T=20°C; 5.5 h;
参考文献
Kaiser, Florian; Schmalz, Hans-Guenther
Tetrahedron, 2003 , vol. 59, # 37 p. 7345 - 7355
反应条件
1: potassium carbonate
2: sodium hydroxide / ethanol
3: thionyl chloride / toluene
4: 1,3-bis-(1-adamantyl)imidazolinium tetrafluoroborate; palladium diacetate; n-ethyl morpholine / para-xylene / 3 h / 115 - 120 °C / |Inert atmosphere
5: dimethylsulfide; boron trifluoride diethyl etherate / dichloromethane / 20 h / |Inert atmosphere
View Scheme
参考文献
Acerson, Mark J.; Fabick, Kimberly M.; Wong, Yong; Blake, Crystal; Lephart, Edwin D.; Andrus, Merritt B.
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 10 p. 2941 - 2944
反应条件
1: 33 percent / K2CO3 / acetonitrile / Heating
2: 96 percent / K2CO3 / acetonitrile / Heating
3: 96 percent / LiAlH4 / tetrahydrofuran
4: 43 percent / NBS / CCl4
5: 82 percent / DEAD, PPh3 / tetrahydrofuran
6: 45 percent / n-BuLi / tetrahydrofuran / -78 °C
7: 54 percent / PDC / dimethylformamide
8: 81 percent / Bu4(NH4), KMnO4, pyridine / dimethylformamide
9: K2CO3 / dimethylformamide
10: 81 percent / Pd(OH)2/C, cyclohexene / ethanol / Heating
View Scheme
参考文献
Ohashi, Hiroshi; Ueno, Akihiro; Nakao, Toyoo; Ito, Junko; Kimura, Kaname; Ishikawa, Masaharu; Kawai, Hiroyuki; Iijima, Hiroshi; Osawa, Tatsushi
Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 14 p. 1945 - 1948
反应条件
1: K2CO3 / acetone / 20 h / Heating
2: 90 percent / 10percent aq. NaOH / acetone / 2 h / Heating
3: 65 percent / SOCl2 / benzene / 5 h / Heating
4: 77 percent / (Et)3N / CH2Cl2 / 1.) 0 deg C, 2 h, 2.) RT, overnight
View Scheme
参考文献
Szirmai; Odqvist; Halldin
Journal of Labelled Compounds and Radiopharmaceuticals, 1996 , vol. 38, # 4 p. 309 - 324
