1,3-二苯-1H-吡唑-4-甲醛合成路线 （共 29 条）
反应条件
1: N,N-dimethyl-formamide With 2,4,6-trichloro-1,3,5-triazine T=25°C; 2: 1-phenyl-2-(1"-phenylethylidene)hydrazine; N,N-dimethyl-formamide T=20°C;
参考文献
BURNHAM INSTITUTE FOR MEDICAL RESEARCH
Patent: US2009/105254 A1, 2009 ;
Location in patent: Page/Page column 22 ;
US 20090105254 A1
反应条件
1: acetophenone; phenylhydrazine With acetic acid in ethanol Heating; 2: N,N-dimethyl-formamide With trichlorophosphate T=10°C; Vilsmeier-Haack Formylation; Heating;
参考文献
Nasrullah, Muhammad; Khan, Misbahul Ain; Khan, Muhammad Naeem; Humphrey, Mark G. Humphrey; Nasim, Faizul Hassan; Chaudhry, Faryal; Abidi, Moeena Ghazal; Farooq, Umar; Munawar, Munawar Ali
Asian Journal of Chemistry, 2013 , vol. 25, # 1 p. 419 - 423
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; iron(III) chloride in water; ethyl acetate T=20°C; 4 h;
参考文献
Kumar, R. Senthil; Karthikeyan; Perumal, Paramasivan T.
Canadian Journal of Chemistry, 2008 , vol. 86, # 7 p. 720 - 725
反应条件
1: 92 percent / conc. acetic acid / ethanol / 1 h / 20 °C 2: 95 percent / POCl3 / 5 h / 70 - 80 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 37, # 8 p. 671 - 679
反应条件
2: trichlorophosphate View Scheme
参考文献
Synthetic Communications, , vol. 41, # 1 p. 136 - 146
反应条件
in N,N-dimethyl-formamide T=70 - 80°C; Vilsmeier-Haack Formylation; 6 h;
参考文献
Bioorganic and Medicinal Chemistry, , vol. 21, # 10 p. 2772 - 2777
反应条件
trichlorophosphate T=70 - 80°C; Vilsmeier-Haack reaction; 5 h;
参考文献
Rathelot, Pascal; Azas, Nadine; El-Kashef, Hussein; Delmas, Florence; Di Giorgio, Carole; Timon-David, Pierre; Maldonado, Jose; Vanelle, Patrice
European Journal of Medicinal Chemistry, 2002 , vol. 37, # 8 p. 671 - 679
反应条件
potassium phosphate; tetrakis(triphenylphosphine) palladium(0); potassium bromide in 1,4-dioxane Suzuki-Miyaura cross-coupling reaction; 2 h; Inert atmosphereReflux;
参考文献
Arbaciauskiene, Egle; Martynaitis, Vytas; Krikstolaityte, Sonata; Holzer, Wolfgang; Sackus, Algirdas
Arkivoc, 2011 , vol. 2011, # 11 p. 1 - 21
反应条件
1: 92 percent / conc. acetic acid / ethanol / 1 h / 20 °C 2: 95 percent / POCl3 / 5 h / 70 - 80 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 37, # 8 p. 671 - 679
反应条件
trichlorophosphate T=0 - 83°C; Vilsmeier-Haack Formylation; 2.5 h; Temperature;
参考文献
Helvetica Chimica Acta, , vol. 96, # 3 p. 452 - 457
