2,6-二甲基苯基溴化镁合成路线 （共 31 条）
反应条件
NiCl2((PPh3)P)2 in tetrahydrofuran 24 h; Ambient temperature; Yield given;
参考文献
Macchia, Bruno; Bylund, David B.; Calderone, Vincenzo; Giannaccini, Gino; Lucacchini, Antonio; Macchia, Marco; Martinelli, Adriano; Martinotti, Enrica; Orlandini, Elisabetta; Romagnoli, Federico; Rossello, Armando
European Journal of Medicinal Chemistry, 1998 , vol. 33, # 11 p. 911 - 919
反应条件
hydrogenchloride in tetrahydrofuran
参考文献
Bristol-Myers Squibb Co.
Patent: US6235740 B1, 2001 ;
US 6235740 B1
参考文献
Geier III, G. Richard; Lindsey, Jonathan S.
Tetrahedron, 2004 , vol. 60, # 50 p. 11435 - 11444
反应条件
[Fe(n-propylamino-N,N-bis(2-methylene-4-tert-butyl-6-methylphenolate))(chloride)]2 in diethyl ether T=100°C; 0.166667 h; Microwave irradiationGlovebox; Catalytic behavior; TemperatureWavelengthTime;
参考文献
UNIVERSITY OF PRINCE EDWARD ISLAND; GENESIS GROUP INC.; SHAVER, Michael, P.; KOZAK, Christopher, M.
Patent: WO2013/53046 A1, 2013 ;
Location in patent: Paragraph 00187-00191 ;
反应条件
C54H80Cl2Fe2N2O4 in diethyl ether T=100°C; 0.166667 h; Inert atmosphereMicrowave irradiation;
参考文献
Qian, Xin; Dawe, Louise N.; Kozak, Christopher M.
Dalton Transactions, 2011 , vol. 40, # 4 p. 933 - 943
反应条件
C46H55ClFeN3Pd; lithium chloride in tetrahydrofuran T=60°C; Kumada coupling reaction; 24 h; Inert atmosphere;
参考文献
Ren, Gerui; Cui, Xiuling; Wu, Yangjie
European Journal of Organic Chemistry, 2010 , # 12 p. 2372 - 2378
参考文献
Watanabe, Soichiro; Goto, Kei; Kawashima, Takayuki; Okazaki, Renji
Tetrahedron Letters, 1995 , vol. 36, # 42 p. 7677 - 7680
反应条件
in tetrahydrofuran; diethyl ether in vac. or under N2 or Ar, addn. of xylylmagnesium bromide in Et2O to a stirred soln. of OsO4 in THF at -78°C, allowed to warm to room temp., 1 h at room temp.; removal of solvent, addn. of hexane, stirred overnight, filtered, concd., cooled to -20°C; elem. anal.;
参考文献
Longley, Cindy J.; Savage, Paul D.; Wilkinson, Geoffrey; Hussain, Bilquis; Hursthouse, Michael B.
Polyhedron, 1988 , vol. 7, p. 1079 - 1088
参考文献
Spivey, Alan C.; Fekner, Tomasz; Spey, Sharon E.
Journal of Organic Chemistry, 2000 , vol. 65, # 10 p. 3154 - 3159
反应条件
1: 2,6-dimethylphenyl MgBr With zinc(II) chloride in tetrahydrofuran
T=20°C; 0.333333 h;
2: ortho-chlorotoluene With Pd0(tris(tert-butyl)phosphine)2 in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=100°C; Negishi reaction; 18 h; Further stages.;
参考文献
Dai; Fu
Journal of the American Chemical Society, 2001 , vol. 123, # 12 p. 2719 - 2724
