4-甲氧基-5-(3-(吗啉-4-基)丙氧基)-2-硝基苯甲酸甲酯合成路线 （共 8 条）
反应条件
sulfuric acid; nitric acid; sodium hydroxide in water; acetic acid T=5 - 20°C;
参考文献
Shih, Kae-Shyang; Hsieh, Yu-Jung; Liu, Ching-Wei
Patent: US2010/267949 A1, 2010 ;
Location in patent: Page/Page column 6 ;
反应条件
potassium carbonate in N,N-dimethyl-formamide T=50 - 100°C; 1 h;
参考文献
Shih, Kae-Shyang; Hsieh, Yu-Jung; Liu, Ching-Wei
Patent: US2010/267949 A1, 2010 ;
Location in patent: Page/Page column 5-6 ;
反应条件
potassium carbonate in acetonitrile 2.5 h; Reflux;
参考文献
IND-SWIFT LABORATORIES LIMITED; AGGARWAL, Ashvin, Kumar; JAIN, Anshul, Kumar; CHIDAMBARAM, Venkateswaran, Srinivasan; WADHWA, Lalit
Patent: WO2010/76810 A2, 2010 ;
Location in patent: Page/Page column 16 ;
反应条件
1: 76 percent / potassium carbonate / acetone / 24 h / Heating 2: 82 percent / nitric acid; trifluoroacetic acid / CH2Cl2 / 2 h / 20 °C 3: 60 percent / 1 h / 100 °C View Scheme
参考文献
Wissner, Allan; Brawner Floyd; Rabindran, Sridhar K.; Nilakantan, Ramaswamy; Greenberger, Lee M.; Shen, Ru; Wang, Yu-Fen; Tsou, Hwei-Ru
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 20 p. 2893 - 2897
参考文献
Seimbille, Yann; Phelps, Michael E.; Czernin, Johannes; Silverman, Daniel H. S.
Journal of Labelled Compounds and Radiopharmaceuticals, 2005 , vol. 48, # 11 p. 829 - 843
反应条件
1: 82 percent / nitric acid; trifluoroacetic acid / CH2Cl2 / 2 h / 20 °C 2: 60 percent / 1 h / 100 °C View Scheme
参考文献
Seimbille, Yann; Phelps, Michael E.; Czernin, Johannes; Silverman, Daniel H. S.
Journal of Labelled Compounds and Radiopharmaceuticals, 2005 , vol. 48, # 11 p. 829 - 843
反应条件
1: hydrogen / palladium on activated carbon / methanol 2: 78 percent / 2-methoxy-ethanol / 2 h / 115 °C 3: oxalyl chloride / CHCl3; dimethylformamide / Heating 4: 70 percent / dimethylformamide / 1 h / 145 °C View Scheme
参考文献
Seimbille, Yann; Phelps, Michael E.; Czernin, Johannes; Silverman, Daniel H. S.
Journal of Labelled Compounds and Radiopharmaceuticals, 2005 , vol. 48, # 11 p. 829 - 843
反应条件
1: hydrogen / palladium on activated carbon / methanol 2: 78 percent / 2-methoxy-ethanol / 2 h / 115 °C View Scheme
参考文献
Seimbille, Yann; Phelps, Michael E.; Czernin, Johannes; Silverman, Daniel H. S.
Journal of Labelled Compounds and Radiopharmaceuticals, 2005 , vol. 48, # 11 p. 829 - 843
