2,3,4-三羟基苯甲醛合成路线 （共 12 条）
反应条件
2: diethyl ether View Scheme
参考文献
Spaeth; Boschan
Monatshefte fuer Chemie, 1933 , vol. 63, p. 142
反应条件
1: 74 percent / N,N-diisopropylethylamine / CH2Cl2 / 1 h / 0 - 20 °C 2: 72 percent / N,N-diisopropylethylamine / acetonitrile; methanol; hexane / 20 °C 3: 89 percent / aq. HCl / methanol / 1 h / Heating View Scheme
参考文献
Saito, Shizuka; Kawabata, Jun
Tetrahedron, 2005 , vol. 61, # 34 p. 8101 - 8108
反应条件
1: 3.5 g / anhydrous K2CO3 / acetone / 0.25 h / Heating 2: KOH / ethanol / 72 h / Ambient temperature 3: K2CO3 / acetone / 3 h / Heating 4: 0.25 g / 3 N HCl / methanol / 0.25 h / Heating View Scheme
参考文献
Wang, Zengtao; Liu, Zhiguo; Cao, Yongkai; Paudel, Suresh; Yoon, Goo; Cheon, Seung Hoon
Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 12 p. 3906 - 3908
反应条件
potassium carbonate in acetone
参考文献
Sugihara,H. et al.
Justus Liebigs Annalen der Chemie, 1972 , vol. 763, p. 109 - 120
参考文献
Spaeth; Boschan
Monatshefte fuer Chemie, 1933 , vol. 63, p. 142
反应条件
1: With sodium hydroxide
T=80°C;
2: With sodium cyanoborohydride in tetrahydrofuran
Further byproducts given;
参考文献
Lambert, Maja; Olsen, Lars; Jaroszewski, Jerzy W.
Journal of Organic Chemistry, 2006 , vol. 71, # 25 p. 9449 - 9457
反应条件
1.1: sodium hydride / 1.5 h / -10 °C / Inert atmosphere
1.2: 20 °C
2.1: boron trichloride / dichloromethane / 2 h / 20 - 25 °C
2.3: pH ~ 1
View Scheme
参考文献
ALLERGAN, INC.; HEIDELBAUGH, Todd M.; CAPPIELLO, John R.; NGUYEN, Phong; GOMEZ, Dario G.
Patent: WO2011/50054 A2, 2011 ;
WO 2011/050054 A1
反应条件
1: With sodium acetate; acetic anhydride
2: in methanol
Acidic aq. solution;
参考文献
Xiao, Chun Fen; Tao, Li Yang; Sun, Hong Yi; Wei, Wen; Chen, Yu; Fu, Li Wu; Zou, Yong
Chinese Chemical Letters, 2010 , vol. 21, # 11 p. 1295 - 1298
反应条件
zinc(II) chloride; trichlorophosphate
T=70°C; 3 h;
参考文献
Li, Nian-Guang; Wang, Jin-Xin; Liu, Xiao-Rong; Lin, Chang-Jun; You, Qi-Dong; Guo, Qing-Long
Tetrahedron Letters, 2007 , vol. 48, # 37 p. 6586 - 6589
反应条件
1: acetic acid; concentrated aqueous hydrochloric acid
2: palladium/charcoal; ethanol / Hydrogenation
4: chromium (VI)-oxide; acetic acid / 100 °C
5: concentrated sulfuric acid
View Scheme
参考文献
Tanase
Yakugaku Zasshi, 1941 , vol. 61, p. 341,346
