1-[1,1'-联苯]-2-基-乙酮合成路线 （共 59 条）
反应条件
1.1: LDA / tetrahydrofuran / 1 h / 0 °C
1.2: 80 percent / 0.5 h / 0 °C
2.1: 70 percent / AIBN; Ph3SnH / xylene / 2 h / Heating
View Scheme
参考文献
Clive; Kang
Journal of Organic Chemistry, 2001 , vol. 66, # 18 p. 6083 - 6091
反应条件
1.1: PCC
2.1: LDA / tetrahydrofuran / 1 h / 0 °C
2.2: 80 percent / 0.5 h / 0 °C
3.1: 70 percent / AIBN; Ph3SnH / xylene / 2 h / Heating
View Scheme
参考文献
Clive; Kang
Journal of Organic Chemistry, 2001 , vol. 66, # 18 p. 6083 - 6091
反应条件
N-ethyl-N,N-diisopropylamine in methanol; ethylene glycol dimethyl ether; water
T=120°C; Suzuki-Miyaura Coupling; 0.228333 h; Flow reactor; Reagent/catalystTime;
参考文献
Reynolds, William R.; Plucinski, Pawel; Frost, Christopher G.
Catalysis Science and Technology, 2014 , vol. 4, # 4 p. 948 - 954
反应条件
sodium carbonate in water; N,N-dimethyl-formamide
T=75 - 80°C; Suzuki coupling; 2.5 h; Microwave irradiation;
参考文献
Berardi, Serena; Carraro, Mauro; Iglesias, Manuel; Sartorel, Andrea; Scorrano, Gianfranco; Albrecht, Martin; Bonchio, Marcella
Chemistry - A European Journal, 2010 , vol. 16, # 35 p. 10662 - 10666
反应条件
Pd2(p-tolyl)2(.mu.-I)(.mu.-N,N'-bis[2-(diphenylphosphino)phenyl]formamidinato); potassium carbonate in benzene
T=100°C; Suzuki-Miyaura Coupling; 17 h; Overall yield = 82 percent;
参考文献
Tsukada, Naofumi; Abe, Tsubasa; Inoue, Yoshio
Helvetica Chimica Acta, 2013 , vol. 96, # 6 p. 1093 - 1102
反应条件
palladium diacetate; trifluoroacetic acid; silver(l) oxide
T=120°C; 20 h; Inert atmosphere; regioselective reaction;
参考文献
Gandeepan, Parthasarathy; Parthasarathy, Kanniyappan; Cheng, Chien-Hong
Journal of the American Chemical Society, 2010 , vol. 132, # 25 p. 8569 - 8571
反应条件
1: diethyl ether
2: CrO3 / aq. acetic acid
View Scheme
参考文献
Wiemann,J. et al.
Bulletin de la Societe Chimique de France, 1967 , p. 2935 - 2945
反应条件
1: 1,1'-bis-(diphenylphosphino)ferrocene; [Ni0(1,5-cyclooctadiene)2]; N,N-dicyclohexylmethylamine / 1,4-dioxane / 20 h / 100 °C / Inert atmosphere
2: hydrogenchloride / 1,4-dioxane; water / 1 h / 20 °C / Inert atmosphere
View Scheme
参考文献
Gogsig, Thomas M.; Kleimark, Jonatan; Nilsson Lill, Sten O.; Korsager, Signe; Lindhardt, Anders T.; Norrby, Per-Ola; Skrydstrup, Troels
Journal of the American Chemical Society, 2012 , vol. 134, # 1 p. 443 - 452
反应条件
magnesium oxide
T=400°C;
参考文献
Wiemann,J. et al.
Bulletin de la Societe Chimique de France, 1967 , p. 2935 - 2945
反应条件
1: toluene / 12 h / 20 °C
2: ruthenium(II)-carbonyl-tris(triphenylphosphine) dihydride; 3,3-dimethyl-butan-2-one / 2 h / 110 °C
View Scheme
参考文献
Peschiulli, Aldo; Smout, Veerle; Storr, Thomas E.; Mitchell, Emily A.; Elias, Zdenek; Herrebout, Wouter; Berthelot, Didier; Meerpoel, Lieven; Maes, Bert U. W.
Chemistry - A European Journal, 2013 , vol. 19, # 31 p. 10378 - 10387
