1-[1,1'-联苯]-2-基-乙酮合成路线 （共 59 条）
反应条件
potassium dihydrogenphosphate; palladium diacetate in ethanol; water
T=77 - 80°C; Suzuki-Miyaura cross-coupling; 3.5 h;
参考文献
Guo, Sheng-Rong; Yuan, Yan-Qin
Journal of Chemical Research, 2009 , # 12 p. 745 - 749
反应条件
P(NC5H10)3; nickel dichloride in tetrahydrofuran; 1-methyl-pyrrolidin-2-one
T=60°C; Negishi cross-coupling reaction; 1 h;
参考文献
Gerber, Roman; Frech, Christian M.
Chemistry - A European Journal, 2011 , vol. 17, # 42 p. 11893 - 11904
反应条件
iron (III) acetylacetonate; 1,2-dichloro-2-methylpropane; magnesium; 4,4'-di-tert-butyl-2,2'-dipyridyl in tetrahydrofuran; 1,4-dioxane; 1,2-dichloro-ethane
T=0°C; 24 h; Inert atmosphere;
参考文献
Ilies, Laurean; Kobayashi, Motoaki; Matsumoto, Arimasa; Yoshikai, Naohiko; Nakamura, Eiichi
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 4 p. 593 - 596
反应条件
in diethyl ether
T=5 - 10°C; 0.5 h;
参考文献
Stillings, Michael R.; Welbourn, Anthony P.; Walter, Donald S.
Journal of Medicinal Chemistry, 1986 , vol. 29, # 11 p. 2280 - 2284
反应条件
tetrabutyl ammonium fluoride; bis(dibenzylideneacetone)-palladium(0); 2-dicyclohexylphosphino-1,1'-biphenyl in tetrahydrofuran
6 h; Heating;
参考文献
Seganish, W. Michael; DeShong, Philip
Journal of Organic Chemistry, 2004 , vol. 69, # 4 p. 1137 - 1143
反应条件
1: phenyl-magnesium bromide With ZnCl2*TMEDA in tetrahydrofuran
T=0°C; Inert atmosphere;
2: N-(1-(4-bromophenyl)ethylidene)-4-methoxybenzenamine With iron (III) acetylacetonate; 1,2-dichloro-2-methylpropane; 4,4'-di-tert-butyl-2,2'-dipyridyl in tetrahydrofuran
T=0°C; 48 h; Inert atmosphere;
3: With hydrogenchloride; water in tetrahydrofuran
T=20°C; 3 h; chemoselective reaction;
参考文献
Yoshikai, Naohiko; Matsumoto, Arimasa; Norinder, Jakob; Nakamura, Eiichi
Angewandte Chemie, International Edition, 2009 , vol. 48, # 16 p. 2925 - 2928
反应条件
1: phenyl-magnesium bromide With ZnCl2*TMEDA in tetrahydrofuran
T=0°C; Inert atmosphere;
2: N-(1-(4-iodophenyl)ethylidene)-4-methoxybenzenamine With iron (III) acetylacetonate; 1,2-dichloro-2-methylpropane; 4,4'-di-tert-butyl-2,2'-dipyridyl in tetrahydrofuran
T=0°C; 3 h; Inert atmosphere;
3: With hydrogenchloride; water in tetrahydrofuran
T=20°C; 3 h; chemoselective reaction;
参考文献
Yoshikai, Naohiko; Matsumoto, Arimasa; Norinder, Jakob; Nakamura, Eiichi
Angewandte Chemie, International Edition, 2009 , vol. 48, # 16 p. 2925 - 2928
反应条件
potassium dichromate; sulfuric acid; acetic acid
T=40 - 50°C;
参考文献
Huber et al.
Journal of the American Chemical Society, 1946 , vol. 68, p. 1109,1111
反应条件
2,2'-azo-bisisobutyronitrile; triphenylstannane in xylene
2 h; Heating;
参考文献
Clive; Kang
Journal of Organic Chemistry, 2001 , vol. 66, # 18 p. 6083 - 6091
反应条件
tetrakis(triphenylphosphine) palladium(0); poly(ethylene glycol)-400; sodium acetate
T=100°C; Stille cross-coupling; 2 h;
参考文献
Zhou, Wen-Jun; Wang, Ke-Hu; Wang, Jin-Xian
Journal of Organic Chemistry, 2009 , vol. 74, # 15 p. 5599 - 5602
