1-[1,1'-联苯]-2-基-乙酮合成路线 （共 59 条）
反应条件
1: 44 percent / methanol / 16 h / 0 °C 2: methanol / 1.5 h / 20 °C / Irradiation View Scheme
参考文献
Dorra, Michael; Gomann, Klaus; Guth, Michael; Kirmse, Wolfgang
Journal of Physical Organic Chemistry, 1996 , vol. 9, # 9 p. 598 - 610
反应条件
hydrogen bromide; dimethyl sulfoxide T=55°C; 24 h;
参考文献
Journal of Organic Chemistry, , vol. 50, # 25 p. 5022 - 5027
反应条件
palladium diacetate; i-Pr2NPPh2; potassium carbonate in tetrahydrofuran
Suzuki-Miyamura cross-coupling reaction; 48 h; Heating;
参考文献
Cheng, Jiang; Wang, Feng; Xu, Jian-Hua; Pan, Yi; Zhang, Zhaoguo
Tetrahedron Letters, 2003 , vol. 44, # 37 p. 7095 - 7098
反应条件
1: monophenyl triethoxy silane With cesium fluoride in 1-methyl-pyrrolidin-2-one
T=20°C; 1 h;
2: 2'-bromoacetophenone With (1-benzyl-4-aza-1-azoniabicyclo[2.2.2]octane)2Pd2Cl6 in 1-methyl-pyrrolidin-2-one
T=20 - 100°C; Hiyama Coupling; 0.233333 h; Microwave irradiation;
参考文献
Hajipour, Abdol R.; Rafiee, Fatemeh; Najafi, Narges
Applied Organometallic Chemistry, 2014 , vol. 28, # 4 p. 217 - 220
反应条件
[Pd{C6H2(CH2CH2NH2)–(OMe)2-2,3}(μ-Br)]2; potassium carbonate in N,N-dimethyl-formamide
T=90°C; Stille Cross Coupling; 0.116667 h; Microwave irradiation;
参考文献
Hajipour, Abdol R.; Rafiee, Fatemeh
Applied Organometallic Chemistry, 2013 , vol. 27, # 7 p. 412 - 418
反应条件
tetrabutylammomium bromide; potassium carbonate; Pd(NH3)2Cl2 in water
T=140°C; Suzuki cross-coupling reaction; 18 h;
参考文献
Wu, Wei-Yi; Chen, Shao-Nung; Tsai, Fu-Yu
Tetrahedron Letters, 2006 , vol. 47, # 52 p. 9267 - 9270
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; (9-phenanthrenyl)Ni(II)(PPh3)2Cl; potassium carbonate in toluene
T=110°C; Suzuki Coupling; 24 h; Inert atmosphere;
参考文献
Hu, Feng; Lei, Xiangyang
Tetrahedron, 2014 , vol. 70, # 25 p. 3854 - 3858
反应条件
sodium carbonate; iron oxide nanoparticle supported-Pd catalyst in N,N-dimethyl-formamide
T=50°C; Suzuki cross-coupling; 12 h;
参考文献
Stevens, Philip D.; Fan, Jinda; Gardimalla, Hari M. R.; Yen, Max; Gao, Yong
Organic Letters, 2005 , vol. 7, # 11 p. 2085 - 2088
反应条件
1: phenyl-magnesium chloride in tetrahydrofuran; ethylene glycol dimethyl ether
T=-20°C; 0.166667 h;
2: o-acetyl-iodobenzene With iron (III) acetylacetonate in tetrahydrofuran; ethylene glycol dimethyl ether
T=-20 - 25°C; 1 h;
参考文献
Sapountzis, Ioannis; Lin, Wenwei; Kofink, Christiane C.; Despotopoulou, Christina; Knochel, Paul
Angewandte Chemie - International Edition, 2005 , vol. 44, # 11 p. 1654 - 1657
反应条件
1: phenyl-magnesium bromide With ZnCl2*TMEDA in tetrahydrofuran
T=0°C; Inert atmosphere;
2: N-(4-methoxy-phenyl)-(1-phenyl-ethylidene)-amine With iron (III) acetylacetonate; 1,2-dichloro-2-methylpropane; 4,4'-di-tert-butyl-2,2'-dipyridyl in tetrahydrofuran
T=0°C; 20 h; Inert atmosphere;
3: With hydrogenchloride; water in tetrahydrofuran
T=20°C; 3 h; chemoselective reaction;
参考文献
Yoshikai, Naohiko; Matsumoto, Arimasa; Norinder, Jakob; Nakamura, Eiichi
Angewandte Chemie, International Edition, 2009 , vol. 48, # 16 p. 2925 - 2928
