N-苯基-1-(2-苯乙基)-4-哌啶胺合成路线 （共 9 条）
反应条件
1: With acetic acid in toluene T=50 - 60°C; 0.25 h; 2: With sodium tris(acetoxy)borohydride in toluene T=0 - 20°C; 20 h; 3: With sodium hydroxide; water in toluene 0.5 h;
参考文献
Boehringer Ingelheim Chemicals, Inc.
Patent: US2006/100438 A1, 2006 ;
Location in patent: Page/Page column 3 ;
反应条件
sodium tetrahydroborate in methanol
参考文献
Vardanyan, Ruben; Vijay, Gokhale; Nichol, Gary S.; Liu, Lu; Kumarasinghe, Isuru; Davis, Peg; Vanderah, Todd; Porreca, Frank; Lai, Josephine; Hruby, Victor J.
Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 14 p. 5044 - 5053
反应条件
sodium hydroxide T=120°C; Product distribution / selectivity;
参考文献
WO2009/116084 A2, ;
Page/Page column 9 ;
反应条件
1.1: triethylamine / CH2Cl2 / 0.5 h / 20 °C 1.2: sodium triacetoxyborohydride / CH2Cl2 / 24 h / 20 °C 2.1: sodium triacetoxyborohydride; acetic acid / CH2Cl2 / 24 h / 20 °C View Scheme
参考文献
Journal of Chemical Research, , # 7 p. 452 - 453
反应条件
1.1: triethylamine / CH2Cl2 / 0.5 h / 20 °C 1.2: sodium triacetoxyborohydride / CH2Cl2 / 24 h / 20 °C 2.1: sodium triacetoxyborohydride; acetic acid / CH2Cl2 / 24 h / 20 °C View Scheme
参考文献
Journal of Chemical Research, , # 7 p. 452 - 453
反应条件
1: With hydrogenchloride; water T=100°C; 72 h; 2: With ammonium hydroxide
参考文献
Wichitnithad, Wisut; McManus, Terence J.; Callery, Patrick S.
Rapid Communications in Mass Spectrometry, 2010 , vol. 24, # 17 p. 2547 - 2553
反应条件
in toluene 3 h; Heating;
参考文献
Brine; Boldt; Huang; Sawyer; Carroll
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 3 p. 677 - 686
反应条件
triethylamine in dichloromethane T=0 - 20°C;
参考文献
AUSPEX PHARMACEUTICALS, INC.
Patent: US2010/16365 A1, 2010 ;
Location in patent: Page/Page column 19-20 ;
US 20100016365 A1
反应条件
in toluene 2 h; Heating;
参考文献
Brine; Boldt; Huang; Sawyer; Carroll
Journal of Heterocyclic Chemistry, 1989 , vol. 26, # 3 p. 677 - 686
