6-氟-3,4-二氢-2H-异喹啉-1-酮合成路线 （共 12 条）
反应条件
1: With sodium azide; methanesulfonic acid in dichloromethane T=0°C; 2.33333 h; 2: With sodium hydroxide in dichloromethane; water 0.5 h;
参考文献
XENTION LIMITED; HAMLYN, Richard, John; MADGE, David; MULLA, Mushtaq
Patent: WO2010/139953 A1, 2010 ;
Location in patent: Page/Page column 37 ;
WO 2010/139953 A1
反应条件
1: With triethylamine in dichloromethane T=20°C; 2: With AlCl3, aluminium chloride in dichloromethane T=0 - 20°C;
参考文献
Berthel, Steven; Firooznia, Fariborz; Fishlock, Daniel; Hong, Jun-Bae; Lou, Yan; Lucas, Matthew; Owens, Timothy D.; Sarma, Keshab; Sweeney, Zachary Kevin; Taygerly, Joshua Paul Gergely
Patent: US2010/222325 A1, 2010 ;
Location in patent: Page/Page column 79 ;
US 20100222325 A1
反应条件
trifluorormethanesulfonic acid T=0 - 70°C; 25 h;
参考文献
Journal of Organic Chemistry, , vol. 77, # 20 p. 9313 - 9328,16
反应条件
1: piperidine; pyridine / 12 h / 75 °C 2: palladium 10 on activated carbon / methanol 3: chlorosulfonic acid 4: trifluoroacetic acid; sodium azide View Scheme
参考文献
WO2012/35078 A1, ;
WO 2012/035078 A1
反应条件
1: palladium 10 on activated carbon / methanol 2: chlorosulfonic acid 3: trifluoroacetic acid; sodium azide View Scheme
参考文献
WO2012/35078 A1, ;
WO 2012/035078 A1
反应条件
1: triethylamine / N,N-dimethyl-formamide / 1 h / 0 - 25 °C 2: trifluorormethanesulfonic acid / 25 h / 0 - 70 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 77, # 20 p. 9313 - 9328,16
反应条件
1: chlorosulfonic acid 2: trifluoroacetic acid; sodium azide View Scheme
参考文献
WO2012/35078 A1, ;
WO 2012/035078 A1
反应条件
hydrazine hydrate T=110°C; 0.25 h; Microwave irradiation;
参考文献
Branca, Danila; Cerretani, Mauro; Jones, Philip; Koch, Uwe; Orvieto, Federica; Palumbi, Maria Cecilia; Rowley, Michael; Toniatti, Carlo; Muraglia, Ester
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 15 p. 4042 - 4045
反应条件
2,3-dicyano-5,6-dichloro-p-benzoquinone in 1,4-dioxane T=100°C; 24 h; Inert atmosphere;
参考文献
Berthel, Steven; Firooznia, Fariborz; Fishlock, Daniel; Hong, Jun-Bae; Lou, Yan; Lucas, Matthew; Owens, Timothy D.; Sarma, Keshab; Sweeney, Zachary Kevin; Taygerly, Joshua Paul Gergely
Patent: US2010/222325 A1, 2010 ;
Location in patent: Page/Page column 80 ;
US 20100222325 A1
反应条件
1: With diborane in tetrahydrofuran T=0°C; 18 h; Heating / reflux; 2: With water in tetrahydrofuran T=20°C;
参考文献
Valeant Pharmaceuticals North America
Patent: US2008/139610 A1, 2008 ;
Location in patent: Page/Page column 21 ;
US 20080139610 A1
