2'-O-甲基鸟苷水合物合成路线 （共 21 条）
反应条件
calf spleen adenosine deaminase; sodium salt of phosphorous acid in dimethyl sulfoxide T=20°C; pH=7.4; 36 h;
参考文献
Kore, Anilkumar; Parmar, Gaurang; Reddy, Srinu
Nucleosides, Nucleotides and Nucleic Acids, 2006 , vol. 25, # 3 p. 307 - 314
反应条件
triethylamine tris(hydrogen fluoride) in tetrahydrofuran T=35°C; 14 h;
参考文献
Chow, Suetying; Wen, Ke; Sanghvi, Yogesh S.; Theodorakis, Emmanuel A.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 10 p. 1631 - 1634
Title/Abstract Full Text View citing articles Show Details
Chow, Suetying; Wen; Sanghvi, Yogesh S; Theodorakis, Emmanuel A
Nucleosides, nucleotides and nucleic acids, 2003 , vol. 22, # 5-8 p. 583 - 587
反应条件
1,4-diaza-bicyclo[2.2.2]octane in water T=90°C; Oxidation; 0.75 h;
参考文献
Beigelman, Leonid; Haeberli, Peter; Sweedler, David; Karpeisky, Alexander
Tetrahedron, 2000 , vol. 56, # 8 p. 1047 - 1056
反应条件
in methanol; N,N-dimethyl-formamide T=70°C; 1 h; Further byproducts given;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 2787 - 2792
反应条件
naphthalene; sodium in tetrahydrofuran dealkylation;
参考文献
Beigelman, Leonid; Haeberli, Peter; Sweedler, David; Karpeisky, Alexander
Tetrahedron, 2000 , vol. 56, # 8 p. 1047 - 1056
反应条件
in dimethyl sulfoxide
反应条件
nickel in water T=100°C; 6 h; Heating / reflux; Product distribution / selectivity;
参考文献
US2008/234475 A1, ;
Page/Page column 8 ;
参考文献
Ribozyme Pharmaceuticals, Inc.
Patent: US5962675 A1, 1999 ;
反应条件
copper acetylacetonate in N,N-dimethyl-formamide T=70°C; 1 h; Further byproducts given;
参考文献
Journal of Organic Chemistry, , vol. 45, # 19 p. 3865 - 3868
反应条件
1: 79 percent / imidazole / dimethylformamide / 5 h / 0 - 25 °C 2: 83 percent / NaHMDS / dimethylformamide / 5 h / -40 - -27 °C 3: 91 percent / Et3N*3HF / tetrahydrofuran / 14 h / 35 °C View Scheme
参考文献
Nucleosides, nucleotides and nucleic acids, , vol. 22, # 5-8 p. 583 - 587
