acetyl chloride in methanol T=20°C; 2 h; Inert atmosphere;

Jacobsen's (S,S)-(salen)Co(III) catalyst; water; toluene-4-sulfonic acid 20 h; optical yield given as percent ee;

1: sodium hydride / Inert atmosphere 2: acetyl chloride / methanol / Inert atmosphere View Scheme

1: L-proline / dimethyl sulfoxide / 1 h / 25 °C 2: methanol; sodium tetrahydroborate / dimethyl sulfoxide / 0.17 h / 0 °C 3: palladium 10 on activated carbon; hydrogen / ethyl acetate / 12 h / 760.05 Torr View Scheme

di-isopropyl azodicarboxylate; triphenylphosphine in toluene RefluxInert atmosphere;